Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK Signaling in a Mouse Model of Alzheimer's Disease.
Alzheimer’s disease
MAPK
human umbilical cord-derived mesenchymal stem cells
neuroinflammation
resveratrol
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
11
2019
accepted:
02
03
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are promising for the treatment of Alzheimer's disease (AD). However, their low rate of migration and survival in the brain limit their clinical applicability. This study is designed to improve the therapeutic potential of hUC-MSCs by preincubating them with resveratrol, a natural polyphenol capable of regulating cell destiny. Herein, we demonstrate that resveratrol preincubation enhances the migration of hUC-MSCs
Identifiants
pubmed: 32292331
doi: 10.3389/fncel.2020.00062
pmc: PMC7118399
doi:
Types de publication
Journal Article
Retracted Publication
Langues
eng
Pagination
62Commentaires et corrections
Type : RetractionIn
Informations de copyright
Copyright © 2020 Wang, Wu, Ma, Xie, Liu, Yao, Zhang, Yang, Yang, Guo and Guan.
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