Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss.
ERK
LPS (lipopolysaccharide)
OVX model
RANKL (receptor activator of nuclear factor kappa-B ligand)
osteoclast (OCs)
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
12
2019
accepted:
10
03
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
Osteolytic bone disease is characterized by excessive osteoclast bone resorption leading to increased skeletal fragility and fracture risk. Multinucleated osteoclasts formed through the fusion of mononuclear precursors are the principle cell capable of bone resorption. Pregnenolone (Preg) is the grand precursor of most if not all steroid hormones and have been suggested to be a novel anti-osteoporotic agent. However, the effects of Preg on osteoclast biology and function has yet to be shown. Here we examined the effect of Preg on receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast formation and bone resorption
Identifiants
pubmed: 32292342
doi: 10.3389/fphar.2020.00360
pmc: PMC7135856
doi:
Types de publication
Journal Article
Langues
eng
Pagination
360Informations de copyright
Copyright © 2020 Sun, Zhang, Guo, Chen, Tao, Wang, Lin, Liu, Su and Qin.
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