Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment.


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
09 Apr 2020
Historique:
received: 20 11 2019
accepted: 10 02 2020
entrez: 16 4 2020
pubmed: 16 4 2020
medline: 16 4 2020
Statut: epublish

Résumé

Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in

Identifiants

pubmed: 32292570
doi: 10.1021/acsmedchemlett.9b00537
pmc: PMC7153278
doi:

Types de publication

Journal Article

Langues

eng

Pagination

605-610

Informations de copyright

Copyright © 2020 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Niklas G Johansson (NG)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Ainoleena Turku (A)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Keni Vidilaseris (K)

Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56 (Viikinkaari 9), FI-00014 Helsinki, Finland.

Loïc Dreano (L)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Ayman Khattab (A)

Malaria Research Laboratory, Translational Immunology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P.O. Box 21 (Haartmaninkatu 3), FI-00014 Helsinki, Finland.

Daniel Ayuso Pérez (D)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Aaron Wilkinson (A)

School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, United Kingdom.

Yuezhou Zhang (Y)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Matti Tamminen (M)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Evgeni Grazhdankin (E)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Alexandros Kiriazis (A)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Colin W G Fishwick (CWG)

School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, United Kingdom.

Seppo Meri (S)

Malaria Research Laboratory, Translational Immunology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P.O. Box 21 (Haartmaninkatu 3), FI-00014 Helsinki, Finland.

Jari Yli-Kauhaluoma (J)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Adrian Goldman (A)

Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56 (Viikinkaari 9), FI-00014 Helsinki, Finland.
School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Clarendon Way, Leeds LS2 9JT, United Kingdom.

Gustav Boije Af Gennäs (G)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Henri Xhaard (H)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), FI-00014 Helsinki, Finland.

Classifications MeSH