Causes and Consequences of Variable Tumor Cell Metabolism on Heritable Modifications and Tumor Evolution.
acidosis and oxidative stress
epigenetic regulation
nutrient sensing and signaling
tumor evolution
tumor micoenvironment
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
12
2019
accepted:
03
03
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
When cancer research advanced into the post-genomic era, it was widely anticipated that the sought-after cure will be delivered promptly. Instead, it became apparent that an understanding of cancer genomics, alone, is unable to translate the wealth of information into successful cures. While gene sequencing has significantly improved our understanding of the natural history of cancer and identified candidates for therapeutic targets, it cannot predict the impact of the biological response to therapies. Hence, patients with a common mutational profile may respond differently to the same therapy, due in part to different microenvironments impacting on gene regulation. This complexity arises from a feedback circuit involving epigenetic modifications made to genes by the metabolic byproducts of cancer cells. New insights into epigenetic mechanisms, activated early in the process of carcinogenesis, have been able to describe phenotypes which cannot be inferred from mutational analyses
Identifiants
pubmed: 32292719
doi: 10.3389/fonc.2020.00373
pmc: PMC7119341
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
373Informations de copyright
Copyright © 2020 Ordway, Swietach, Gillies and Damaghi.
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