Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1
amyotrophic lateral sclerosis (ALS)
drug delivery
nanoparticle
neurodegeneration and neuroprotection
retinoic acid signaling
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
11
2019
accepted:
05
03
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
Dysregulation of the retinoic acid (RA) signaling pathway is observed in amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here, we investigated the therapeutic potential of retinoid activation via the RA receptor β (RARβ) in the SOD1
Identifiants
pubmed: 32292776
doi: 10.3389/fbioe.2020.00224
pmc: PMC7118553
doi:
Types de publication
Journal Article
Langues
eng
Pagination
224Informations de copyright
Copyright © 2020 Medina, Chung, Teague, Bowser and Sirianni.
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