Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases.
aging-related tau astrogliopathy
argyrophilic grain
granular/fuzzy astrocyte
primary age-related tauopathy
tau
tufted astrocyte
Journal
Brain pathology (Zurich, Switzerland)
ISSN: 1750-3639
Titre abrégé: Brain Pathol
Pays: Switzerland
ID NLM: 9216781
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
23
10
2019
revised:
03
04
2020
accepted:
06
04
2020
pubmed:
16
4
2020
medline:
23
6
2021
entrez:
16
4
2020
Statut:
ppublish
Résumé
Granular/fuzzy astrocytes (GFAs), a subtype of "aging-related tau astrogliopathy," are noted in cases bearing various neurodegenerative diseases. However, the pathogenic significance of GFAs remains unclear. We immunohistochemically examined the frontal cortex, caudate nucleus, putamen and amygdala in 105 cases composed of argyrophilic grain disease cases (AGD, N = 26), and progressive supranuclear palsy (PSP, N = 10), Alzheimer's disease (AD, N = 20) and primary age-related tauopathy cases (PART, N = 18) lacking AGD, as well as 31 cases bearing other various neurodegenerative diseases to clarify (i) the distribution patterns of GFAs in AGD, and PSP, AD and PART lacking AGD, (ii) the impacts of major pathological factors and age on GFA formation and (iii) immunohistochemical features useful to understand the formation process of GFAs. In AGD cases, GFAs consistently occurred in the amygdala (100%), followed by the putamen (69.2%) and caudate nucleus and frontal cortex (57.7%, respectively). In PSP cases without AGD, GFAs were almost consistently noted in all regions examined (90-100%). In AD cases without AGD, GFAs were less frequent, developing preferably in the putamen (35.0%) and caudate nucleus (30.0%). PART cases without AGD had GFAs most frequently in the amygdala (35.3%), being more similar to AGD than to AD cases. Ordered logistic regression analyses using all cases demonstrated that the strongest independent factor of GFA formation in the frontal cortex and striatum was the diagnosis of PSP, while that in the amygdala was AGD. The age was not significantly associated with GFA formation in any region. In GFAs in AGD cases, phosphorylation and conformational change of tau, Gallyas-positive glial threads indistinguishable from those in tufted astrocytes, and the activation of autophagy occurred sequentially. Given these findings, AGD, PSP, AD and PART cases may show distinct distributions of GFAs, which may provide clues to predict the underlying processes of primary tauopathies.
Identifiants
pubmed: 32293067
doi: 10.1111/bpa.12843
pmc: PMC7383906
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
811-830Subventions
Organisme : National Center of Neurology and Psychiatry
ID : 30-8
Pays : International
Organisme : Japan Agency for Medical Research and Development
ID : JP19dm0107109
Pays : International
Organisme : Zikei Institute of Psychiatry
Pays : International
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 18K07559
Pays : International
Organisme : Ministry of Health, Labour and Welfare
ID : H29-Nanchi-Ippan-033
Pays : International
Informations de copyright
© 2020 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.
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