The role of mitochondrial dynamics in cardiovascular diseases.
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
31
03
2020
received:
24
12
2019
accepted:
01
04
2020
pubmed:
16
4
2020
medline:
6
7
2021
entrez:
16
4
2020
Statut:
ppublish
Résumé
The process of mitochondrial dynamics is emerging as a core player in cardiovascular homeostasis. This process refers to the co-ordinated cycles of biogenesis, fusion, fission and degradation to which mitochondria constantly undergo to maintain their integrity, distribution and size. These mechanisms represent an early response to mitochondrial stress, confining organelle portions that are irreversibly damaged and preserving mitochondrial function. Accumulating evidence demonstrates that impairment in mitochondrial dynamics leads to myocardial damage and cardiac disease progression in a variety of disease models, including pressure overload, ischaemia/reperfusion and metabolic disturbance. These findings suggest that modulation of mitochondrial dynamics may be considered as a valid therapeutic strategy in cardiovascular diseases. In this review, we discuss the current evidence about the role of mitochondrial dynamics in cardiac pathophysiology, with a particular focus on the mechanisms underlying the development of cardiac hypertrophy and heart failure, metabolic and genetic cardiomyopathies, ischaemia/reperfusion injury, atherosclerosis and ischaemic stroke. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2060-2076Informations de copyright
© 2020 The British Pharmacological Society.
Références
Alavi, M. V., Bette, S., Schimpf, S., Schuettauf, F., Schraermeyer, U., Wehrl, H. F., … Knipper, M. (2007). A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Brain, 130, 1029-1042.
Alexander, S. P. H., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., … Southan, C. (2019). The Concise Guide to pharmacology 2019/20: Introduction and other protein targets. British Journal of Pharmacology, 176(Suppl 1), S1-S20.
Anand, R., Wai, T., Baker, M. J., Kladt, N., Schauss, A. C., Rugarli, E., & Langer, T. (2014). The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. The Journal of Cell Biology, 204, 919-929. https://doi.org/10.1083/jcb.201308006
Ashrafian, H., Docherty, L., Leo, V., Towlson, C., Neilan, M., Steeples, V., … Dear, T. N. (2010). A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genetics, 6, e1001000. https://doi.org/10.1371/journal.pgen.1001000
Barsoum, M. J., Yuan, H., Gerencser, A. A., Liot, G., Kushnareva, Y., Graber, S., … White, A. D. (2006). Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. The EMBO Journal, 25, 3900-3911. https://doi.org/10.1038/sj.emboj.7601253
Basu, K., Lajoie, D., Aumentado-Armstrong, T., Chen, J., Koning, R. I., Bossy, B., … Rouiller, I. (2017). Molecular mechanism of DRP1 assembly studied in vitro by cryo-electron microscopy. PLoS ONE, 12, e0179397. https://doi.org/10.1371/journal.pone.0179397
Bhandari, P., Song, M., Chen, Y., Burelle, Y., & Dorn, G. W. 2nd (2014). Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circulation Research, 114, 257-265. https://doi.org/10.1161/CIRCRESAHA.114.302734
Bonneau, D., Colin, E., Oca, F., Ferre, M., Chevrollier, A., Gueguen, N., … Rio, M. (2014). Early-onset Behr syndrome due to compound heterozygous mutations in OPA1. Brain, 137, e301. https://doi.org/10.1093/brain/awu184
Bonora, M., Wieckowski, M. R., Sinclair, D. A., Kroemer, G., Pinton, P., & Galluzzi, L. (2019). Targeting mitochondria for cardiovascular disorders: Therapeutic potential and obstacles. Nature Reviews. Cardiology, 16, 33-55.
Bossy-Wetzel, E., Barsoum, M. J., Godzik, A., Schwarzenbacher, R., & Lipton, S. A. (2003). Mitochondrial fission in apoptosis, neurodegeneration and aging. Current Opinion in Cell Biology, 15, 706-716.
Burman, J. L., Pickles, S., Wang, C., Sekine, S., Vargas, J. N. S., Zhang, Z., … Youle, R. J. (2017). Mitochondrial fission facilitates the selective mitophagy of protein aggregates. The Journal of Cell Biology, 216, 3231-3247. https://doi.org/10.1083/jcb.201612106
Cahill, T. J., Leo, V., Kelly, M., Stockenhuber, A., Kennedy, N. W., Bao, L., … Ashrafian, H. (2015). Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. The Journal of Biological Chemistry, 290, 25,907-25,919. https://doi.org/10.1074/jbc.M115.665695
Chaanine, A. H., Joyce, L. D., Stulak, J. M., Maltais, S., Joyce, D. L., Dearani, J. A., … Redfield, M. M. (2019). Mitochondrial morphology, dynamics, and function in human pressure overload or ischemic heart disease with preserved or reduced ejection fraction. Circulation. Heart Failure, 12, e005131.
Chaanine, A. H., Kohlbrenner, E., Gamb, S. I., Guenzel, A. J., Klaus, K., Fayyaz, A. U., … Redfield, M. M. (2016). FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress. American Journal of Physiology. Heart and Circulatory Physiology, 311, H1540-H1559. https://doi.org/10.1152/ajpheart.00549.2016
Chan, D. C. (2006). Mitochondrial fusion and fission in mammals. Annual Review of Cell and Developmental Biology, 22, 79-99.
Chandran, K., Aggarwal, D., Migrino, R. Q., Joseph, J., McAllister, D., Konorev, E. A., … Kalyanaraman, B. (2009). Doxorubicin inactivates myocardial cytochrome c oxidase in rats: Cardioprotection by Mito-Q. Biophysical Journal, 96, 1388-1398. https://doi.org/10.1016/j.bpj.2008.10.042
Chang, C. R., & Blackstone, C. (2007a). Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. The Journal of Biological Chemistry, 282, 21,583-21,587.
Chang, C. R., & Blackstone, C. (2007b). Drp1 phosphorylation and mitochondrial regulation. EMBO Reports, 8, 1088-1089. author reply 1089-1090
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003). Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. The Journal of Cell Biology, 160, 189-200.
Chen, H., McCaffery, J. M., & Chan, D. C. (2007). Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell, 130, 548-562.
Chen, H., Ren, S., Clish, C., Jain, M., Mootha, V., McCaffery, J. M., & Chan, D. C. (2015). Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy. The Journal of Cell Biology, 211, 795-805. https://doi.org/10.1083/jcb.201507035
Chen, K. H., Guo, X., Ma, D., Guo, Y., Li, Q., Yang, D., … Tang, J. (2004). Dysregulation of HSG triggers vascular proliferative disorders. Nature Cell Biology, 6, 872-883. https://doi.org/10.1038/ncb1161
Chen, L., Gong, Q., Stice, J. P., & Knowlton, A. A. (2009). Mitochondrial OPA1, apoptosis, and heart failure. Cardiovascular Research, 84, 91-99.
Chen, L., Liu, T., Tran, A., Lu, X., Tomilov, A. A., Davies, V., … Knowlton, A. A. (2012). OPA1 mutation and late-onset cardiomyopathy: Mitochondrial dysfunction and mtDNA instability. Journal of the American Heart Association, 1, e003012.
Chen, M., Chen, Z., Wang, Y., Tan, Z., Zhu, C., Li, Y., … Chen, Q. (2016). Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy, 12, 689-702. https://doi.org/10.1080/15548627.2016.1151580
Chen, Y., Csordas, G., Jowdy, C., Schneider, T. G., Csordas, N., Wang, W., … Nerbonne, J. M. (2012). Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk. Circulation Research, 111, 863-875. https://doi.org/10.1161/CIRCRESAHA.112.266585
Chen, Y., & Dorn, G. W. 2nd (2013). PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science, 340, 471-475.
Chen, Y., Liu, Y., & Dorn, G. W. 2nd (2011). Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circulation Research, 109, 1327-1331.
Cipolat, S., Martins de Brito, O., Dal Zilio, B., & Scorrano, L. (2004). OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proceedings of the National Academy of Sciences of the United States of America, 101, 15,927-15,932.
Dai, D. F., Rabinovitch, P. S., & Ungvari, Z. (2012). Mitochondria and cardiovascular aging. Circulation Research, 110, 1109-1124.
Davies, V. J., Hollins, A. J., Piechota, M. J., Yip, W., Davies, J. R., White, K. E., … Votruba, M. (2007). Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function. Human Molecular Genetics, 16, 1307-1318. https://doi.org/10.1093/hmg/ddm079
de Brito, O. M., & Scorrano, L. (2008). Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature, 456, 605-610.
Di, W., Lv, J., Jiang, S., Lu, C., Yang, Z., Ma, Z., … Xu, B. (2018). PGC-1: The energetic regulator in cardiac metabolism. Current Issues in Molecular Biology, 28, 29-46. https://doi.org/10.21775/cimb.028.029
Diguet, N., Trammell, S. A. J., Tannous, C., Deloux, R., Piquereau, J., Mougenot, N., … Mericskay, M. (2018). Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy. Circulation, 137, 2256-2273. https://doi.org/10.1161/CIRCULATIONAHA.116.026099
Din, S., Mason, M., Volkers, M., Johnson, B., Cottage, C. T., Wang, Z., … Sussman, M. A. (2013). Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation. Proceedings of the National Academy of Sciences of the United States of America, 110, 5969-5974. https://doi.org/10.1073/pnas.1213294110
Disatnik, M. H., Ferreira, J. C., Campos, J. C., Gomes, K. S., Dourado, P. M., Qi, X., & Mochly-Rosen, D. (2013). Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. Journal of the American Heart Association, 2, e000461.
Dorn, G. W. 2nd, Clark, C. F., Eschenbacher, W. H., Kang, M. Y., Engelhard, J. T., Warner, S. J., … Jowdy, C. C. (2011). MARF and Opa1 control mitochondrial and cardiac function in Drosophila. Circulation Research, 108, 12-17. https://doi.org/10.1161/CIRCRESAHA.110.236745
Durcan, T. M., Tang, M. Y., Perusse, J. R., Dashti, E. A., Aguileta, M. A., McLelland, G. L., … Coulombe, B. (2014). USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin. The EMBO Journal, 33, 2473-2491. https://doi.org/10.15252/embj.201489729
Eschenbacher, W. H., Song, M., Chen, Y., Bhandari, P., Zhao, P., Jowdy, C. C., … Dorn, G. W. (2012). Two rare human mitofusin 2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology in Drosophila. PLoS ONE, 7, e44296. https://doi.org/10.1371/journal.pone.0044296
Fang, L., Moore, X. L., Gao, X. M., Dart, A. M., Lim, Y. L., & Du, X. J. (2007). Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo. Life Sciences, 80, 2154-2160.
Filadi, R., Pendin, D., & Pizzo, P. (2018). Mitofusin 2: From functions to disease. Cell Death & Disease, 9, 330.
Forte, M., Bianchi, F., Cotugno, M., Marchitti, S., De Falco, E., Raffa, S., … Pagano, F. (2019). Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence. Autophagy, 1-14. https://doi.org/10.1080/15548627.2019.1687215
Forte, M., Palmerio, S., Bianchi, F., Volpe, M., & Rubattu, S. (2019). Mitochondrial complex I deficiency and cardiovascular diseases: Current evidence and future directions. Journal of Molecular Medicine (Berlin, Germany), 97, 579-591.
Franco, A., Kitsis, R. N., Fleischer, J. A., Gavathiotis, E., Kornfeld, O. S., Gong, G., … Dorn, G. W. II (2016). Correcting mitochondrial fusion by manipulating mitofusin conformations. Nature, 540, 74-79. https://doi.org/10.1038/nature20156
Gao, D., Zhang, L., Dhillon, R., Hong, T. T., Shaw, R. M., & Zhu, J. (2013). Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS ONE, 8, e60967.
Gimbrone, M. A. Jr., & Garcia-Cardena, G. (2016). Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circulation Research, 118, 620-636.
Givvimani, S., Munjal, C., Tyagi, N., Sen, U., Metreveli, N., & Tyagi, S. C. (2012). Mitochondrial division/mitophagy inhibitor (Mdivi) ameliorates pressure overload induced heart failure. PLoS ONE, 7, e32388.
Gomes, L. C., & Scorrano, L. (2008). High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochimica et Biophysica Acta, 1777, 860-866.
Gong, G., Song, M., Csordas, G., Kelly, D. P., Matkovich, S. J., & Dorn, G. W. 2nd (2015). Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science, 350, aad2459. https://doi.org/10.1126/science.aad2459
Grohm, J., Kim, S. W., Mamrak, U., Tobaben, S., Cassidy-Stone, A., Nunnari, J., … Culmsee, C. (2012). Inhibition of Drp1 provides neuroprotection in vitro and in vivo. Cell Death and Differentiation, 19, 1446-1458. https://doi.org/10.1038/cdd.2012.18
Guo, C., Hildick, K. L., Luo, J., Dearden, L., Wilkinson, K. A., & Henley, J. M. (2013). SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia. The EMBO Journal, 32, 1514-1528.
Guo, Y., Wang, Z., Qin, X., Xu, J., Hou, Z., Yang, H., … Gao, F. (2018). Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart. Cardiovascular Research, 114, 979-991. https://doi.org/10.1093/cvr/cvy052
Guo, Y. H., Chen, K., Gao, W., Li, Q., Chen, L., Wang, G. S., & Tang, J. (2007). Overexpression of Mitofusin 2 inhibited oxidized low-density lipoprotein induced vascular smooth muscle cell proliferation and reduced atherosclerotic lesion formation in rabbit. Biochemical and Biophysical Research Communications, 363, 411-417. https://doi.org/10.1016/j.bbrc.2007.08.191
Harding, S. D., Sharman, J. L., Faccenda, E., Southan, C., Pawson, A. J., Ireland, S., … Bryant, C. (2017). The IUPHAR/BPS Guide to pharmacology in 2018: Updates and expansion to encompass the new guide to immunopharmacology. Nucleic Acids Research, 46, D1091-D1106.
Hasan, P., Saotome, M., Ikoma, T., Iguchi, K., Kawasaki, H., Iwashita, T., … Maekawa, Y. (2018). Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats. Journal of Molecular and Cellular Cardiology, 121, 103-106. https://doi.org/10.1016/j.yjmcc.2018.07.004
Hoppel, C. L., Tandler, B., Fujioka, H., & Riva, A. (2009). Dynamic organization of mitochondria in human heart and in myocardial disease. The International Journal of Biochemistry & Cell Biology, 41, 1949-1956.
Hoshino, A., Mita, Y., Okawa, Y., Ariyoshi, M., Iwai-Kanai, E., Ueyama, T., … Matoba, S. (2013). Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart. Nature Communications, 4, 2308. https://doi.org/10.1038/ncomms3308
Ikeda, Y., Shirakabe, A., Maejima, Y., Zhai, P., Sciarretta, S., Toli, J., … Sadoshima, J. (2015). Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circulation Research, 116, 264-278. https://doi.org/10.1161/CIRCRESAHA.116.303356
Ishihara, T., Ban-Ishihara, R., Maeda, M., Matsunaga, Y., Ichimura, A., Kyogoku, S., … Ishihara, N. (2015). Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Molecular and Cellular Biology, 35, 211-223. https://doi.org/10.1128/MCB.01054-14
Jahani-Asl, A., Cheung, E. C., Neuspiel, M., MacLaurin, J. G., Fortin, A., Park, D. S., … Slack, R. S. (2007). Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. The Journal of Biological Chemistry, 282, 23,788-23,798. https://doi.org/10.1074/jbc.M703812200
Jin, H. S., Sober, S., Hong, K. W., Org, E., Kim, B. Y., Laan, M., … Jeong, S. Y. (2011). Age-dependent association of the polymorphisms in the mitochondria-shaping gene, OPA1, with blood pressure and hypertension in Korean population. American Journal of Hypertension, 24, 1127-1135. https://doi.org/10.1038/ajh.2011.131
Kageyama, Y., Hoshijima, M., Seo, K., Bedja, D., Sysa-Shah, P., Andrabi, S. A., … Sesaki, H. (2014). Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain. The EMBO Journal, 33, 2798-2813. https://doi.org/10.15252/embj.201488658
Kanzaki, Y., Terasaki, F., Okabe, M., Otsuka, K., Katashima, T., Fujita, S., … Kitaura, Y. (2010). Giant mitochondria in the myocardium of a patient with mitochondrial cardiomyopathy: Transmission and 3-dimensional scanning electron microscopy. Circulation, 121, 831-832. https://doi.org/10.1161/CIR.0b013e3181d22e2d
Karbowski, M., Lee, Y. J., Gaume, B., Jeong, S. Y., Frank, S., Nechushtan, A., … Youle, R. J. (2002). Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. The Journal of Cell Biology, 159, 931-938. https://doi.org/10.1083/jcb.200209124
Kasahara, A., Cipolat, S., Chen, Y., Dorn, G. W. 2nd, & Scorrano, L. (2013). Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. Science, 342, 734-737.
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002). Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes, 51, 2944-2950.
Kim, E. Y., Zhang, Y., Beketaev, I., Segura, A. M., Yu, W., Xi, Y., … Wang, J. (2015). SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy. Journal of Molecular and Cellular Cardiology, 78, 154-164. https://doi.org/10.1016/j.yjmcc.2014.08.003
Kim, H., Scimia, M. C., Wilkinson, D., Trelles, R. D., Wood, M. R., Bowtell, D., … Ronai, Z.'. A. (2011). Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Molecular Cell, 44, 532-544. https://doi.org/10.1016/j.molcel.2011.08.045
Kolleritsch, S., Kien, B., Schoiswohl, G., Diwoky, C., Schreiber, R., Heier, C., … Haemmerle, G. (2019). Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice. Cardiovascular Research. https://doi.org/10.1093/cvr/cvz119
Konstantinidis, K., Lederer, W. J., Rizzuto, R., & Kitsis, R. N. (2012). Mitofusin 2 joins the sarcoplasmic reticulum and mitochondria at the hip to sustain cardiac energetics. Circulation Research, 111, 821-823.
Kraus, B., & Cain, H. (1980). Giant mitochondria in the human myocardium-Morphogenesis and fate. Virchows Archiv. B, Cell Pathology Including Molecular Pathology, 33, 77-89.
Kubli, D. A., Zhang, X., Lee, Y., Hanna, R. A., Quinsay, M. N., Nguyen, C. K., … Gustafsson, Å. B. (2013). Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. The Journal of Biological Chemistry, 288, 915-926. https://doi.org/10.1074/jbc.M112.411363
Labrousse, A. M., Zappaterra, M. D., Rube, D. A., & van der Bliek, A. M. (1999). C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Molecular Cell, 4, 815-826.
Lai, L., Leone, T. C., Zechner, C., Schaeffer, P. J., Kelly, S. M., Flanagan, D. P., … Kelly, D. P. (2008). Transcriptional coactivators PGC-1α and PGC-lβ control overlapping programs required for perinatal maturation of the heart. Genes & Development, 22, 1948-1961. https://doi.org/10.1101/gad.1661708
Lee, S., Jeong, S. Y., Lim, W. C., Kim, S., Park, Y. Y., Sun, X., … Cho, H. (2007). Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. The Journal of Biological Chemistry, 282, 22,977-22,983. https://doi.org/10.1074/jbc.M700679200
Lee, Y., Lee, H. Y., Hanna, R. A., & Gustafsson, A. B. (2011). Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. American Journal of Physiology. Heart and Circulatory Physiology, 301, H1924-H1931.
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000). Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis. The Journal of Clinical Investigation, 106, 847-856.
Liesa, M., Borda-d'Agua, B., Medina-Gomez, G., Lelliott, C. J., Paz, J. C., Rojo, M., … Zorzano, A. (2008). Mitochondrial fusion is increased by the nuclear coactivator PGC-1β. PLoS ONE, 3, e3613. https://doi.org/10.1371/journal.pone.0003613
Lim, S., Lee, S. Y., Seo, H. H., Ham, O., Lee, C., Park, J. H., … Hwang, K. C. (2015). Regulation of mitochondrial morphology by positive feedback interaction between PKCδ and Drp1 in vascular smooth muscle cell. Journal of Cellular Biochemistry, 116, 648-660. https://doi.org/10.1002/jcb.25016
Liu, C., Ge, B., He, C., Zhang, Y., Liu, X., Liu, K., … Guo, X. (2014). Mitofusin 2 decreases intracellular lipids in macrophages by regulating peroxisome proliferator-activated receptor-γ. Biochemical and Biophysical Research Communications, 450, 500-506. https://doi.org/10.1016/j.bbrc.2014.06.005
Liu, X., & Hajnoczky, G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress. Cell Death and Differentiation, 18, 1561-1572.
Ljubicic, V., Menzies, K. J., & Hood, D. A. (2010). Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle. Mechanisms of Ageing and Development, 131, 79-88.
Loson, O. C., Song, Z., Chen, H., & Chan, D. C. (2013). Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Molecular Biology of the Cell, 24, 659-667.
Lutz, A. K., Exner, N., Fett, M. E., Schlehe, J. S., Kloos, K., Lammermann, K., … Bouman, L. (2009). Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. The Journal of Biological Chemistry, 284, 22938-22951. https://doi.org/10.1074/jbc.M109.035774
MacVicar, T., & Langer, T. (2016). OPA1 processing in cell death and disease-The long and short of it. Journal of Cell Science, 129, 2297-2306.
Makino, A., Scott, B. T., & Dillmann, W. H. (2010). Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes. Diabetologia, 53, 1783-1794.
Makino, A., Suarez, J., Gawlowski, T., Han, W., Wang, H., Scott, B. T., & Dillmann, W. H. (2011). Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 300, R1296-R1302. https://doi.org/10.1152/ajpregu.00437.2010
Maneechote, C., Palee, S., Kerdphoo, S., Jaiwongkam, T., Chattipakorn, S. C., & Chattipakorn, N. (2019). Balancing mitochondrial dynamics via increasing mitochondrial fusion attenuates infarct size and left ventricular dysfunction in rats with cardiac ischemia/reperfusion injury. Clinical Science (London, England), 133, 497-513.
Martin, O. J., Lai, L., Soundarapandian, M. M., Leone, T. C., Zorzano, A., Keller, M. P., … Kelly, D. P. (2014). A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circulation Research, 114, 626-636. https://doi.org/10.1161/CIRCRESAHA.114.302562
Montaigne, D., Marechal, X., Coisne, A., Debry, N., Modine, T., Fayad, G., … Staels, B. (2014). Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients. Circulation, 130, 554-564. https://doi.org/10.1161/CIRCULATIONAHA.113.008476
Nagy, R., Boutin, T. S., Marten, J., Huffman, J. E., Kerr, S. M., Campbell, A., … Hayward, C. (2017). Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. Genome Medicine, 9, 23. https://doi.org/10.1186/s13073-017-0414-4
Naruse, G., Kanamori, H., Yoshida, A., Minatoguchi, S., Kawaguchi, T., Iwasa, M., … Minatoguchi, S. (2019). The intestine responds to heart failure by enhanced mitochondrial fusion through glucagon-like peptide-1 signalling. Cardiovascular Research, 115, 1873-1885. https://doi.org/10.1093/cvr/cvz002
Ong, S. B., Subrayan, S., Lim, S. Y., Yellon, D. M., Davidson, S. M., & Hausenloy, D. J. (2010). Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation, 121, 2012-2022.
Papanicolaou, K. N., Khairallah, R. J., Ngoh, G. A., Chikando, A., Luptak, I., O'Shea, K. M., … Walsh, K. (2011). Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Molecular and Cellular Biology, 31, 1309-1328. https://doi.org/10.1128/MCB.00911-10
Papanicolaou, K. N., Kikuchi, R., Ngoh, G. A., Coughlan, K. A., Dominguez, I., Stanley, W. C., & Walsh, K. (2012). Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circulation Research, 111, 1012-1026. https://doi.org/10.1161/CIRCRESAHA.112.274142
Papanicolaou, K. N., Ngoh, G. A., Dabkowski, E. R., O'Connell, K. A., Ribeiro, R. F. Jr., Stanley, W. C., & Walsh, K. (2012). Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death. American Journal of Physiology. Heart and Circulatory Physiology, 302, H167-H179. https://doi.org/10.1152/ajpheart.00833.2011
Park, Y. Y., Lee, S., Karbowski, M., Neutzner, A., Youle, R. J., & Cho, H. (2010). Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. Journal of Cell Science, 123, 619-626.
Parra, V., Verdejo, H. E., Iglewski, M., Del Campo, A., Troncoso, R., Jones, D., … Jana, F. (2014). Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes, 63, 75-88. https://doi.org/10.2337/db13-0340
Patten, D. A., Wong, J., Khacho, M., Soubannier, V., Mailloux, R. J., Pilon-Larose, K., … Slack, R. S. (2014). OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. The EMBO Journal, 33, 2676-2691. https://doi.org/10.15252/embj.201488349
Peng, C., Rao, W., Zhang, L., Wang, K., Hui, H., Wang, L., … Fei, Z. (2015). Mitofusin 2 ameliorates hypoxia-induced apoptosis via mitochondrial function and signaling pathways. The International Journal of Biochemistry & Cell Biology, 69, 29-40. https://doi.org/10.1016/j.biocel.2015.09.011
Pennanen, C., Parra, V., Lopez-Crisosto, C., Morales, P. E., del Campo, A., Gutierrez, T., … Rothermel, B. A. (2014). Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+−calcineurin signaling pathway. Journal of Cell Science, 127, 2659-2671. https://doi.org/10.1242/jcs.139394
Piquereau, J., Caffin, F., Novotova, M., Prola, A., Garnier, A., Mateo, P., … Joubert, F. (2012). Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Cardiovascular Research, 94, 408-417. https://doi.org/10.1093/cvr/cvs117
Prudent, J., Zunino, R., Sugiura, A., Mattie, S., Shore, G. C., & McBride, H. M. (2015). MAPL SUMOylation of Drp1 stabilizes an ER/mitochondrial platform required for cell death. Molecular Cell, 59, 941-955.
Rogers, M. A., Maldonado, N., Hutcheson, J. D., Goettsch, C., Goto, S., Yamada, I., … Aikawa, E. (2017). Dynamin-related protein 1 inhibition attenuates cardiovascular calcification in the presence of oxidative stress. Circulation Research, 121, 220-233. https://doi.org/10.1161/CIRCRESAHA.116.310293
Rossman, M. J., Santos-Parker, J. R., Steward, C. A. C., Bispham, N. Z., Cuevas, L. M., Rosenberg, H. L., … Seals, D. R. (2018). Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults. Hypertension, 71, 1056-1063. https://doi.org/10.1161/HYPERTENSIONAHA.117.10787
Russell, L. K., Mansfield, C. M., Lehman, J. J., Kovacs, A., Courtois, M., Saffitz, J. E., … Kelly, D. P. (2004). Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circulation Research, 94, 525-533. https://doi.org/10.1161/01.RES.0000117088.36577.EB
Sabbah, H. N., Gupta, R. C., Singh-Gupta, V., Zhang, K., & Lanfear, D. E. (2018). Abnormalities of mitochondrial dynamics in the failing heart: Normalization following long-term therapy with elamipretide. Cardiovascular Drugs and Therapy, 32, 319-328.
Saito, T., Nah, J., Oka, S. I., Mukai, R., Monden, Y., Maejima, Y., … Sadoshima, J. (2019). An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia. The Journal of Clinical Investigation, 129, 802-819. https://doi.org/10.1172/JCI122035
Saito, T., & Sadoshima, J. (2015). Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart. Circulation Research, 116, 1477-1490.
Salabei, J. K., & Hill, B. G. (2013). Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation. Redox Biology, 1, 542-551.
Samant, S. A., Zhang, H. J., Hong, Z., Pillai, V. B., Sundaresan, N. R., Wolfgeher, D., … Gupta, M. P. (2014). SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Molecular and Cellular Biology, 34, 807-819. https://doi.org/10.1128/MCB.01483-13
Santel, A., Frank, S., Gaume, B., Herrler, M., Youle, R. J., & Fuller, M. T. (2003). Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. Journal of Cell Science, 116, 2763-2774.
Schiattarella, G. G., & Hill, J. A. (2015). Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload. Circulation, 131, 1435-1447.
Schiattarella, G. G., Hill, T. M., & Hill, J. A. (2017). Is load-induced ventricular hypertrophy ever compensatory? Circulation, 136, 1273-1275.
Sciarretta, S., Maejima, Y., Zablocki, D., & Sadoshima, J. (2018). The role of autophagy in the heart. Annual Review of Physiology, 80, 1-26.
Sharp, W. W., Fang, Y. H., Han, M., Zhang, H. J., Hong, Z., Banathy, A., … Archer, S. L. (2014). Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: Therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. The FASEB Journal, 28, 316-326. https://doi.org/10.1096/fj.12-226225
Shen, T., Zheng, M., Cao, C., Chen, C., Tang, J., Zhang, W., … Xiao, R. P. (2007). Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. The Journal of Biological Chemistry, 282, 23,354-23,361. https://doi.org/10.1074/jbc.M702657200
Shenouda, S. M., Widlansky, M. E., Chen, K., Xu, G., Holbrook, M., Tabit, C. E., … Vita, J. A. (2011). Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation, 124, 444-453. https://doi.org/10.1161/CIRCULATIONAHA.110.014506
Sheridan, C., Delivani, P., Cullen, S. P., & Martin, S. J. (2008). Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Molecular Cell, 31, 570-585.
Shirakabe, A., Ikeda, Y., Sciarretta, S., Zablocki, D. K., & Sadoshima, J. (2016). Aging and autophagy in the heart. Circulation Research, 118, 1563-1576.
Shirakabe, A., Zhai, P., Ikeda, Y., Saito, T., Maejima, Y., Hsu, C. P., … Sadoshima, J. (2016). Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure. Circulation, 133, 1249-1263. https://doi.org/10.1161/CIRCULATIONAHA.115.020502
Sihag, S., Cresci, S., Li, A. Y., Sucharov, C. C., & Lehman, J. J. (2009). PGC-1α and ERRα target gene downregulation is a signature of the failing human heart. Journal of Molecular and Cellular Cardiology, 46, 201-212.
Song, M., Chen, Y., Gong, G., Murphy, E., Rabinovitch, P. S., & Dorn, G. W. 2nd (2014). Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circulation Research, 115, 348-353.
Song, M., Franco, A., Fleischer, J. A., Zhang, L., & Dorn, G. W. 2nd (2017). Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial senescence. Cell Metabolism, 26, 872-883 e875.
Song, M., Gong, G., Burelle, Y., Gustafsson, A. B., Kitsis, R. N., Matkovich, S. J., & Dorn, G. W. II (2015). Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts. Circulation Research, 117, 346-351. https://doi.org/10.1161/CIRCRESAHA.117.306859
Song, M., Mihara, K., Chen, Y., Scorrano, L., & Dorn, G. W. 2nd (2015). Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metabolism, 21, 273-286.
Spiegel, R., Saada, A., Flannery, P. J., Burte, F., Soiferman, D., Khayat, M., … Shaag, A. (2016). Fatal infantile mitochondrial encephalomyopathy, hypertrophic cardiomyopathy and optic atrophy associated with a homozygous OPA1 mutation. Journal of Medical Genetics, 53, 127-131. https://doi.org/10.1136/jmedgenet-2015-103361
Taguchi, N., Ishihara, N., Jofuku, A., Oka, T., & Mihara, K. (2007). Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. The Journal of Biological Chemistry, 282, 11,521-11,529.
Tsushima, K., Bugger, H., Wende, A. R., Soto, J., Jenson, G. A., Tor, A. R., … Abel, E. D. (2018). Mitochondrial reactive oxygen species in lipotoxic hearts induce post-translational modifications of AKAP121, DRP1, and OPA1 that promote mitochondrial fission. Circulation Research, 122, 58-73. https://doi.org/10.1161/CIRCRESAHA.117.311307
Twig, G., Elorza, A., Molina, A. J., Mohamed, H., Wikstrom, J. D., Walzer, G., … Las, G. (2008). Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. The EMBO Journal, 27, 433-446. https://doi.org/10.1038/sj.emboj.7601963
van der Bliek, A. M., Shen, Q., & Kawajiri, S. (2013). Mechanisms of mitochondrial fission and fusion. Cold Spring Harbor Perspectives in Biology, 5(6), a011072.
Varanita, T., Soriano, M. E., Romanello, V., Zaglia, T., Quintana-Cabrera, R., Semenzato, M., … Scorrano, L. (2015). The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metabolism, 21, 834-844. https://doi.org/10.1016/j.cmet.2015.05.007
Vasquez-Trincado, C., Garcia-Carvajal, I., Pennanen, C., Parra, V., Hill, J. A., Rothermel, B. A., & Lavandero, S. (2016). Mitochondrial dynamics, mitophagy and cardiovascular disease. The Journal of Physiology, 594, 509-525. https://doi.org/10.1113/JP271301
Wai, T., Garcia-Prieto, J., Baker, M. J., Merkwirth, C., Benit, P., Rustin, P., … Langer, T. (2015). Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science, 350, aad0116. https://doi.org/10.1126/science.aad0116
Wang, H., Song, P., Du, L., Tian, W., Yue, W., Liu, M., … Zhou, J. (2011). Parkin ubiquitinates Drp1 for proteasome-dependent degradation: Implication of dysregulated mitochondrial dynamics in Parkinson disease. The Journal of Biological Chemistry, 286, 11,649-11,658. https://doi.org/10.1074/jbc.M110.144238
Wang, J., Chen, H., Liu, Y., Zhou, W., Sun, R., & Xia, M. (2015). Retinol binding protein 4 induces mitochondrial dysfunction and vascular oxidative damage. Atherosclerosis, 240, 335-344.
Wang, J. X., Jiao, J. Q., Li, Q., Long, B., Wang, K., Liu, J. P., … Li, P. F. (2011). miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nature Medicine, 17, 71-78. https://doi.org/10.1038/nm.2282
Wang, K., Long, B., Jiao, J. Q., Wang, J. X., Liu, J. P., Li, Q., & Li, P. F. (2012). miR-484 regulates mitochondrial network through targeting Fis1. Nature Communications, 3, 781. https://doi.org/10.1038/ncomms1770
Wang, Q., Zhang, M., Torres, G., Wu, S., Ouyang, C., Xie, Z., & Zou, M. H. (2017). Metformin suppresses diabetes-accelerated atherosclerosis via the inhibition of Drp1-mediated mitochondrial fission. Diabetes, 66, 193-205. https://doi.org/10.2337/db16-0915
Watanabe, T., Saotome, M., Nobuhara, M., Sakamoto, A., Urushida, T., Katoh, H., … Hayashi, H. (2014). Roles of mitochondrial fragmentation and reactive oxygen species in mitochondrial dysfunction and myocardial insulin resistance. Experimental Cell Research, 323, 314-325. https://doi.org/10.1016/j.yexcr.2014.02.027
Waterham, H. R., Koster, J., van Roermund, C. W., Mooyer, P. A., Wanders, R. J., & Leonard, J. V. (2007). A lethal defect of mitochondrial and peroxisomal fission. The New England Journal of Medicine, 356, 1736-1741.
Yu, T., Robotham, J. L., & Yoon, Y. (2006). Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proceedings of the National Academy of Sciences of the United States of America, 103, 2653-2658.
Yu, T., Sheu, S. S., Robotham, J. L., & Yoon, Y. (2008). Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovascular Research, 79, 341-351.
Zepeda, R., Kuzmicic, J., Parra, V., Troncoso, R., Pennanen, C., Riquelme, J. A., … Lavandero, S. (2014). Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury. Journal of Cardiovascular Pharmacology, 63, 477-487. https://doi.org/10.1097/FJC.0000000000000071
Zhang, H., Wang, P., Bisetto, S., Yoon, Y., Chen, Q., Sheu, S. S., & Wang, W. (2017). A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration. Cardiovascular Research, 113, 160-170. https://doi.org/10.1093/cvr/cvw212
Zhao, L., Zou, X., Feng, Z., Luo, C., Liu, J., Li, H., … Liu, J. (2014). Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Experimental Gerontology, 56, 3-12. https://doi.org/10.1016/j.exger.2014.02.001
Zhao, T., Huang, X., Han, L., Wang, X., Cheng, H., Zhao, Y., … Zheng, M. (2012). Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes. The Journal of Biological Chemistry, 287, 23,615-23,625. https://doi.org/10.1074/jbc.M112.379164
Zhao, Y. X., Cui, M., Chen, S. F., Dong, Q., & Liu, X. Y. (2014). Amelioration of ischemic mitochondrial injury and Bax-dependent outer membrane permeabilization by Mdivi-1. CNS Neuroscience & Therapeutics, 20, 528-538.
Zorzano, A., Liesa, M., & Palacin, M. (2009). Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes. The International Journal of Biochemistry & Cell Biology, 41, 1846-1854. https://doi.org/10.1016/j.biocel.2009.02.004
Zuchner, S., Mersiyanova, I. V., Muglia, M., Bissar-Tadmouri, N., Rochelle, J., Dadali, E. L., … Vance, J. M. (2004). Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nature Genetics, 36, 449-451. https://doi.org/10.1038/ng1341