Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding.
functional network
neural code
untuned neurons
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
14 04 2020
14 04 2020
Historique:
received:
07
10
2019
revised:
22
01
2020
accepted:
13
03
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
28
4
2021
Statut:
ppublish
Résumé
Unbiased and dense sampling of large populations of layer 2/3 pyramidal neurons in mouse primary visual cortex (V1) reveals two functional sub-populations: neurons tuned and untuned to drifting gratings. Whether functional interactions between these two groups contribute to the representation of visual stimuli is unclear. To examine these interactions, we summarize the population partial pairwise correlation structure as a directed and weighted graph. We find that tuned and untuned neurons have distinct topological properties, with untuned neurons occupying central positions in functional networks (FNs). Implementation of a decoder that utilizes the topology of these FNs yields accurate decoding of visual stimuli. We further show that decoding performance degrades comparably following manipulations of either tuned or untuned neurons. Our results demonstrate that untuned neurons are an integral component of V1 FNs and suggest that network interactions contain information about the stimulus that is accessible to downstream elements.
Identifiants
pubmed: 32294431
pii: S2211-1247(20)30361-2
doi: 10.1016/j.celrep.2020.03.047
pmc: PMC7218481
mid: NIHMS1584934
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
107483Subventions
Organisme : NEI NIH HHS
ID : R01 EY022338
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH121978
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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