Binary Solutions of Hyaluronan and Lactose-Modified Chitosan: The Influence of Experimental Variables in Assembling Complex Coacervates.
characterization
complex coacervation
experimental variables
hyaluronic acid
lactose-modified chitosan
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
13 Apr 2020
13 Apr 2020
Historique:
received:
27
02
2020
revised:
10
04
2020
accepted:
11
04
2020
entrez:
17
4
2020
pubmed:
17
4
2020
medline:
17
4
2020
Statut:
epublish
Résumé
A miscibility study between oppositely charged polyelectrolytes, namely hyaluronic acid and a lactose-modified chitosan, is here reported. Experimental variables such as polymers' weight ratios, pH values, ionic strengths and hyaluronic acid molecular weights were considered. Transmittance analyses demonstrated the mutual solubility of the two biopolymers at a neutral pH. The onset of the liquid-liquid phase separation due to electrostatic interactions between the two polymers was detected at pH 4.5, and it was found to be affected by the overall ionic strength, the modality of mixing and the polymers' weight ratio. Thorough Dynamic Light Scattering (DLS) measurements were performed to check the quality of the formed coacervates by investigating their dimensions, homogeneity and surface charge. The whole DLS results highlighted the influence of the hyaluronic acid molecular weight in affecting coacervates' dispersity and size.
Identifiants
pubmed: 32294992
pii: polym12040897
doi: 10.3390/polym12040897
pmc: PMC7240600
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Interreg
ID : 1472551605
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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