Impact of Early Antiretroviral Treatment Initiation on Performance of Cross-Sectional Incidence Assays.


Journal

AIDS research and human retroviruses
ISSN: 1931-8405
Titre abrégé: AIDS Res Hum Retroviruses
Pays: United States
ID NLM: 8709376

Informations de publication

Date de publication:
07 2020
Historique:
pubmed: 17 4 2020
medline: 2 7 2021
entrez: 17 4 2020
Statut: ppublish

Résumé

Antiretroviral therapy (ART) can impact assays used for cross-sectional HIV incidence testing, causing inaccurate HIV incidence estimates. We evaluated the relationship between the timing of ART initiation and the performance of two serologic HIV incidence assays. We analyzed 302 samples from 55 individuals from the RV217 cohort (Early Capture HIV Cohort Study). Participants were grouped by ART start time: ART started <1 year after infection (

Identifiants

pubmed: 32295382
doi: 10.1089/AID.2019.0286
pmc: PMC7398433
doi:

Substances chimiques

Anti-Retroviral Agents 0
HIV Antibodies 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

583-589

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI095068
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068613
Pays : United States

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Auteurs

Ethan Klock (E)

The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

George Mwinnya (G)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA.

Leigh Anne Eller (LA)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.

Reinaldo E Fernandez (RE)

The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Hannah Kibuuka (H)

Makerere University Walter Reed Project, Kampala, Uganda.

Sorachai Nitayaphan (S)

Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

Josphat Kosgei (J)

Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
United States Army Medical Research Directorate-Africa/Kenya (USAMRD-A/K), Jericho, Kenya.
Henry Jackson Foundation Medical Research International (HJFMRI), Kericho, Kenya.

Richard D Moore (RD)

The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Merlin Robb (M)

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.

Susan H Eshleman (SH)

The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Oliver Laeyendecker (O)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA.

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Classifications MeSH