Healed Plaques in Patients With Stable Angina Pectoris.

Aged Angina, Stable / pathology Coronary Artery Disease / pathology Coronary Stenosis / pathology Coronary Thrombosis / pathology Coronary Vessels / pathology Female Humans Lipids / analysis Macrophages / pathology Male Middle Aged Plaque, Atherosclerotic / pathology Tomography, Optical Coherence Vascular Calcification / pathology
atherosclerosis macrophage optical coherence tomography stable angina pectoris thrombosis

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
06 2020
Historique:
pubmed: 17 4 2020
medline: 14 7 2020
entrez: 17 4 2020
Statut: ppublish

Résumé

Healed plaques, signs of previous plaque destabilization, are frequently found in the coronary arteries. Healed plaques can now be diagnosed in living patients. We investigated the prevalence, angiographic, and optical coherence tomography features of healed plaques in patients with stable angina pectoris. Approach and Results: Patients with stable angina pectoris who had undergone optical coherence tomography imaging were included. Healed plaques were defined as plaques with one or more signal-rich layers of different optical density. Patients were divided into 2 groups based on layered or nonlayered phenotype at the culprit lesion. Among 163 patients, 87 (53.4%) had layered culprit plaque. Patients with layered culprit plaque had more multivessel disease (62.1% versus 44.7%, In patients with stable angina pectoris, healed culprit plaques are common and have more features of vulnerability and advanced atherosclerosis both at culprit and nonculprit lesions.

Identifiants

DOI: 10.1161/ATVBAHA.120.314298 PMID: 32295419
pubmed: 32295419
doi: 10.1161/ATVBAHA.120.314298
doi:

Substances chimiques

Lipids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1587-1597

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Auteurs

Michele Russo (M)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Francesco Fracassi (F)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Osamu Kurihara (O)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Hyung Oh Kim (HO)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Vikas Thondapu (V)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Makoto Araki (M)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Hiroki Shinohara (H)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Tomoyo Sugiyama (T)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Erika Yamamoto (E)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

Hang Lee (H)

Biostatistics Center (H.L.), Massachusetts General Hospital, Harvard Medical School, Boston.

Rocco Vergallo (R)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy (R.V., F.C., L.M.B.).

Filippo Crea (F)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy (R.V., F.C., L.M.B.).

Luigi Marzio Biasucci (LM)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Department of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Rome, Italy (R.V., F.C., L.M.B.).

Taishi Yonetsu (T)

Department of Interventional Cardiology, Tokyo Medical and Dental University, Japan (T.Y.).

Yoshiyasu Minami (Y)

Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan (Y.M.).

Tsunenari Soeda (T)

Department of Cardiovascular Medicine, Nara Medical University, Japan (T. Soeda).

Valentin Fuster (V)

Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City, NY (V.F.).

Ik-Kyung Jang (IK)

From the Cardiology Division (M.R., F.F., O.K., H.O.K., V.T., M.A., H.S., T. Sugiyama, E.Y., I.-K.J.), Massachusetts General Hospital, Harvard Medical School, Boston.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur thoracique › Angine de poitrine › Angor stable › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Maladie des artères coronaires › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Sténose coronarienne › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Thrombose coronarienne › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Veines › Vaisseaux coronaires › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Lipides › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › Healed Plaques in Patients With Stable Angina Pectoris.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du calcium › Calcinose › Calcification vasculaire › Healed Plaques in Patients With Stable Angina Pectoris.