Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in

Cell Cycle Proteins / genetics Centromere / metabolism Centromere Protein A Chromosomal Proteins, Non-Histone / genetics DNA-Binding Proteins / genetics Humans Protein Serine-Threonine Kinases Proteolysis Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae Proteins / genetics Ubiquitination
CENP-A Cdc7 Centromere Cse4 DDK Psh1

Journal

G3 (Bethesda, Md.)
ISSN: 2160-1836
Titre abrégé: G3 (Bethesda)
Pays: England
ID NLM: 101566598

Informations de publication

Date de publication:
01 06 2020
Historique:
pubmed: 17 4 2020
medline: 22 6 2021
entrez: 17 4 2020
Statut: epublish

Résumé

The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN) in yeast, fly, and human cells and CENP-A is highly expressed and mislocalized in cancers. Defining mechanisms that prevent mislocalization of CENP-A is an area of active investigation. Ubiquitin-mediated proteolysis of overexpressed Cse4 (

Identifiants

DOI: 10.1534/g3.120.401131 PMID: 32295767 PMC: PMC7263675
pubmed: 32295767
pii: g3.120.401131
doi: 10.1534/g3.120.401131
pmc: PMC7263675
doi:

Substances chimiques

Cell Cycle Proteins 0
Centromere Protein A 0
Chromosomal Proteins, Non-Histone 0
DBF4 protein, human 0
DNA-Binding Proteins 0
Dbf4 protein, S cerevisiae 0
Saccharomyces cerevisiae Proteins 0
CDC7 protein, S cerevisiae EC 2.7.1.-
CDC7 protein, human EC 2.7.1.-
Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2057-2068

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM035078
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG005853
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG005084
Pays : United States
Organisme : CIHR
ID : FDN-143264
Pays : Canada

Informations de copyright

Copyright © 2020 Eisenstatt et al.

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Auteurs

Jessica R Eisenstatt (JR)

Genetics Branch, Center for Cancer Research, National Cancer Institute.

Lars Boeckmann (L)

Genetics Branch, Center for Cancer Research, National Cancer Institute.

Wei-Chun Au (WC)

Genetics Branch, Center for Cancer Research, National Cancer Institute.

Valerie Garcia (V)

Genetics Branch, Center for Cancer Research, National Cancer Institute.

Levi Bursch (L)

Genetics Branch, Center for Cancer Research, National Cancer Institute.

Josefina Ocampo (J)

Division of Developmental Biology, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20894.

Michael Costanzo (M)

Department of Molecular Genetics.
Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.

Michael Weinreich (M)

Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503.

Robert A Sclafani (RA)

Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado 80045.
ORCID: 0000-0002-1100-6489

Anastasia Baryshnikova (A)

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544.

Chad L Myers (CL)

Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, and.

Charles Boone (C)

Department of Molecular Genetics.
Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.

David J Clark (DJ)

Division of Developmental Biology, Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20894.

Richard Baker (R)

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655.

Munira A Basrai (MA)

Genetics Branch, Center for Cancer Research, National Cancer Institute, basraim@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Centromère › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Protéine A du centromère › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Métabolisme › Protéolyse › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Dbf4-Dependent Kinase (DDK)-Mediated...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Dbf4-Dependent Kinase (DDK)-Mediated...