Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice.
aging
apelin
apelin receptor (APJ)
cell loss
knock-out
retinal ganglion cell (RGC)
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
07
2019
accepted:
19
02
2020
entrez:
17
4
2020
pubmed:
17
4
2020
medline:
17
4
2020
Statut:
epublish
Résumé
Age-associated loss of retinal ganglion cells (RGCs) causes visual deficits, but there is not yet any therapeutic agent to prevent the loss of these cells. Herein, we report that apelin, an endogenous peptide ligand of APJ receptor, is protective against the age-related loss of RGCs in mice. The mRNA expression of apelin was reduced in the retina of old mice compared with that in young mice, whereas retinal APJ expression increased with age. Immunofluorescence staining showed that APJ was present in RGCs and their surrounding cells expressed apelin. In addition, both functional and histological analyses demonstrated that apelin deficiency accelerated the loss of RGCs associated with age in mice. These results suggest that endogenous apelin plays a protective role against the degeneration of RGCs and that the apelinergic axis may be a new target for preventing age-related visual impairment.
Identifiants
pubmed: 32296325
doi: 10.3389/fnagi.2020.00058
pmc: PMC7141441
doi:
Types de publication
Journal Article
Langues
eng
Pagination
58Informations de copyright
Copyright © 2020 Ishimaru, Sumino, Shibagaki, Yamamuro, Yoshioka and Maeda.
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