Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis.

acute pancreatitis immunosuppression lymphocyte lymphopenia secondary infection

Journal

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359

Informations de publication

Date de publication:
2020
Historique:
received: 12 10 2019
accepted: 09 03 2020
entrez: 17 4 2020
pubmed: 17 4 2020
medline: 22 6 2021
Statut: epublish

Résumé

Acute pancreatitis (AP) is considered a cascade of immune responses triggered by acinar cell necrosis. AP involves two main processes of systemic inflammatory response syndrome and subsequent compensatory anti-inflammatory response syndrome. Although great efforts have been made regarding AP therapy, the mortality rate of AP remains high. Secondary infection acts a lethal factor in AP. Lymphocytes act as major immune mediators in immune responses in the course of this disease. However, the relationship between lymphocytes and secondary infection in AP is unclear. This review summarizes the variation of lymphocytes and infection in AP. Knowledge of the characterization of circulating lymphocyte abnormalities is relevant for understanding the pathophysiology of AP.

Identifiants

pubmed: 32296650
doi: 10.3389/fcimb.2020.00128
pmc: PMC7136471
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

128

Informations de copyright

Copyright © 2020 Ding, Yang, Li, Wang and Gao.

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Auteurs

Lili Ding (L)

Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.

Yimin Yang (Y)

Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.

Hongxiang Li (H)

Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.

Haijiao Wang (H)

Department of Gynecology Oncology, The First Hospital of Jilin University, Changchun, China.

Pujun Gao (P)

Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, China.

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Classifications MeSH