The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population.
Inflammatory biomarkers
MNA
Malnutrition risk
Older persons
Journal
European geriatric medicine
ISSN: 1878-7649
Titre abrégé: Eur Geriatr Med
Pays: Switzerland
ID NLM: 101533694
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
07
11
2019
accepted:
19
02
2020
pubmed:
17
4
2020
medline:
19
8
2021
entrez:
17
4
2020
Statut:
ppublish
Résumé
Malnutrition is an underestimated, but significant problem among older persons. It is described as a consequence of genetic and environmental factors, lack of physical activity, and co-morbidities. However, a key role of a geriatrician is to further explore the multidimensional complexity of this issue. The aim of this study was to identify the relationship between nutritional status and different factors, particularly focusing on inflammatory biomarkers. Nutritional status was assessed using Mini-Nutritional-Assessment with a score below 24 (out of 30) defined as malnutrition. Different serum biomarkers of inflammation were measured, such as High-Sensitivity-C-Reactive-Protein (hsCRP), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-18(IL-18), osteoprotegerin(OPG), and Soluble-Receptor-For-TNF-alfa(sTNFRII). Medical history, mental status (Mini-Mental-State-Examination, Geriatric-Depression-Scale) and activities of daily living (using Instrumental-Activities-of-Daily-Living-Scale) were used in the evaluation. The relationship between nutritional status and the factors listed was assessed. The mean age of 76 examined persons (40.8% female) from the outpatient clinic was 71 years. Malnutrition risk was recognized in 29%. The following factors significant in univariate regression were used in stepwise regression analysis: age, sex, mental status (MMSE, GDS), valve disease, number of diseases, IADL. Stepwise regression revealed that the risk of malnutrition was increased by the presence of valve disease, number of diseases, and female sex. Factors that increased the risk of malnutrition were: logsTNFRII (OR = 3.09; 95% CI 1.07-8.96), IL-8 (OR = 1.09; 95% CI 1.00-1.18), and OPG (OR = 1.27; 95% CI 1.02-1.57). Risk of malnutrition was negatively associated with Il-18(OR = 0.995; 95% CI 0.991-0.999). Chronic inflammation and immunologic process are likely contributors to the complex etiopathogenesis of malnutrition in older persons.
Identifiants
pubmed: 32297262
doi: 10.1007/s41999-020-00303-4
pii: 10.1007/s41999-020-00303-4
pmc: PMC7280354
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
383-391Subventions
Organisme : Uniwersytet Jagielloński Collegium Medicum
ID : K/ZDS/004 507
Pays : International
Références
Clin Nutr. 2006 Dec;25(6):962-7
pubmed: 16859814
Immunol Rev. 2018 Jan;281(1):138-153
pubmed: 29247988
Egypt J Immunol. 2005;12(1):125-31
pubmed: 16734147
Ageing Res Rev. 2011 Jul;10(3):319-29
pubmed: 21145432
Clin Nutr. 2007 Dec;26(6):728-35
pubmed: 17949861
Asia Pac J Clin Nutr. 2010;19(3):440-9
pubmed: 20805090
Am J Kidney Dis. 2006 Jan;47(1):139-48
pubmed: 16377395
Rom J Morphol Embryol. 2013;54(4):935-8
pubmed: 24398988
Circ Heart Fail. 2011 Mar;4(2):145-52
pubmed: 21216833
Front Immunol. 2013 Dec 23;4:478
pubmed: 24391650
Nutr Cancer. 2012;64(1):41-7
pubmed: 22098075
J Nutr Sci Vitaminol (Tokyo). 2015;61(3):263-9
pubmed: 26226964
J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1183-9
pubmed: 19622801
Protein Sci. 1997 Mar;6(3):598-608
pubmed: 9070442
PLoS One. 2014 Mar 05;9(3):e89457
pubmed: 24599060
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9
pubmed: 24833586
Nature. 2003 May 15;423(6937):337-42
pubmed: 12748652
Circulation. 2002 Jul 2;106(1):24-30
pubmed: 12093765
Am J Clin Nutr. 2006 Feb;83(2):447S-455S
pubmed: 16470011
Respir Med. 2010 Dec;104(12):1883-9
pubmed: 20627502
Public Health Nutr. 2009 Jan;12(1):82-90
pubmed: 18413012
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
Atherosclerosis. 2011 Dec;219(2):925-30
pubmed: 22015178
Nutr Hosp. 2012 Jul-Aug;27(4):1049-59
pubmed: 23165541
Eur Geriatr Med. 2020 Feb;11(1):169-177
pubmed: 32297234
Psychol Neuropsychiatr Vieil. 2006 Dec;4(4):281-6
pubmed: 17194648
Nutrients. 2019 Mar 03;11(3):
pubmed: 30832404
Ther Apher Dial. 2018 Oct;22(5):519-529
pubmed: 29974642
J Clin Med. 2019 Apr 20;8(4):
pubmed: 31010015
Asia Pac J Clin Nutr. 2018;27(3):527-532
pubmed: 29737798
Sci Rep. 2015 Dec 16;5:18332
pubmed: 26669254
PLoS One. 2012;7(8):e44242
pubmed: 22957004
Clin Nutr. 2019 Feb;38(1):1-9
pubmed: 30181091
Stroke. 2009 Mar;40(3):e66-74
pubmed: 19164799
Clin Nutr. 2008 Dec;27(6):793-9
pubmed: 18718696
Cell Res. 2011 Apr;21(4):558-60
pubmed: 21283134
Nutr Hosp. 2018 Jan 18;35(2):461-468
pubmed: 29756982
Ageing Res Rev. 2014 Nov;18:112-31
pubmed: 25257179
Eur J Clin Nutr. 2016 Mar;70(3):320-5
pubmed: 26153193
Autoimmunity. 2007 Nov;40(7):529-31
pubmed: 17966043
Br J Nutr. 2010 Jul;104(1):93-9
pubmed: 20193094
J Nutr Health Aging. 2000;4(4):246-51
pubmed: 11115810
J Am Geriatr Soc. 2018 Dec;66(12):2335-2343
pubmed: 30136728
Pol Arch Med Wewn. 2013;123(4):149-55
pubmed: 23535831
Int J Cardiol. 2002 Sep;85(1):15-21
pubmed: 12163206
Eur Geriatr Med. 2019 Aug;10(4):619-624
pubmed: 34652737
Eur J Clin Invest. 2011 May;41(5):498-506
pubmed: 21128937
PLoS One. 2016 Aug 22;11(8):e0157919
pubmed: 27548305
Med Pregl. 2007;60 Suppl 2:114-6
pubmed: 18928174
Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):15-21
pubmed: 21076295
J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):165-73
pubmed: 23689826
Scand J Immunol. 2016 Jan;83(1):58-63
pubmed: 26448366
J Gerontol A Biol Sci Med Sci. 2002 May;57(5):M326-32
pubmed: 11983728