Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment.
Journal
Lab on a chip
ISSN: 1473-0189
Titre abrégé: Lab Chip
Pays: England
ID NLM: 101128948
Informations de publication
Date de publication:
07 05 2020
07 05 2020
Historique:
pubmed:
17
4
2020
medline:
20
1
2021
entrez:
17
4
2020
Statut:
ppublish
Résumé
Lymphatic vessels (LVs) have been suggested as a preferential conduit for metastatic progression in breast cancer, where a correlation between the occurrence of lymph node metastasis and an increased extracellular matrix (ECM) density has been reported. However, the effect of ECM density on LV function is largely unknown. To better understand these effects, we used a microfluidic device to recreate tubular LVs in a collagen type I matrix. The density of the matrix was tailored to mimic normal breast tissue using a low-density collagen (LD-3 mg mL
Identifiants
pubmed: 32297896
doi: 10.1039/d0lc00099j
pmc: PMC7330815
mid: NIHMS1587920
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1586-1600Subventions
Organisme : NIDCR NIH HHS
ID : P50 DE026787
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA186134
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB010039
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA225281
Pays : United States
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