Bridging Bacteria and the Gut: Functional Aspects of Type IV Pili.
commensal
fimbriae
microbiome
microbiota–host interactions
pathogen
type IV pili
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
26
09
2019
revised:
31
01
2020
accepted:
10
02
2020
entrez:
17
4
2020
pubmed:
17
4
2020
medline:
1
6
2021
Statut:
ppublish
Résumé
Cell-surface-located proteinaceous appendages, such as flagella and fimbriae or pili, are ubiquitous in bacterial communities. Here, we focus on conserved type IV pili (T4P) produced by bacteria in the intestinal tract, one of the most densely populated human ecosystems. Computational analysis revealed that approximately 30% of known intestinal bacteria are predicted to produce T4P. To rationalize how T4P allow intestinal bacteria to interact with their environment, other microbiota members, and host cells, we review their established role in gut commensals and pathogens with respect to adherence, motility, and biofilm formation, as well as protein secretion and DNA uptake. This work indicates that T4P are widely spread among the known members of the intestinal microbiota and that their contribution to human health might be underestimated.
Identifiants
pubmed: 32298612
pii: S0966-842X(20)30027-5
doi: 10.1016/j.tim.2020.02.003
pii:
doi:
Substances chimiques
Fimbriae Proteins
147680-16-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
340-348Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.