The Human Spleen in Malaria: Filter or Shelter?

Erythrocytes / immunology Humans Malaria, Falciparum / immunology Plasmodium falciparum / physiology Spleen / immunology
Plasmodium artemisinin gametocytes hyper-reactive malarial splenomegaly malaria spleen

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
05 2020
Historique:
received: 02 11 2019
revised: 10 02 2020
accepted: 04 03 2020
entrez: 17 4 2020
pubmed: 17 4 2020
medline: 2 12 2020
Statut: ppublish

Résumé

The human spleen is an immune sentinel and controls red blood cell (RBC) quality. By mechanically retaining subsets of infected RBCs, the spleen may reduce the pace at which the parasite biomass increases before the adaptive immune response operates. Conversely, the spleen may contribute to malaria pathogenesis, particularly anemia that is associated with splenomegaly. Large spleens may also shelter parasites in chronic carriers. Upon treatment with artemisinins, the spleen clears circulating parasites by pitting and releases 'once-infected' RBCs in circulation. This triggers postartesunate delayed hemolysis and explains the long post-treatment positivity of histidine-rich protein 2 (HRP2)-based dipsticks. Importantly, splenic retention of RBCs also applies to gametocytes, the clearance of which may be enhanced by stiffening them with drugs, a potential way to block malaria transmission.

Identifiants

DOI: 10.1016/j.pt.2020.03.001 PMID: 32298631
pubmed: 32298631
pii: S1471-4922(20)30060-X
doi: 10.1016/j.pt.2020.03.001
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

435-446

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Auteurs

Benoît Henry (B)

Université de Paris, Biologie Intégrée du Globule Rouge, UMR_S1134, BIGR, INSERM, F-75015 Paris, France; Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75015 Paris, France; Laboratoire d'Excellence Gr-Ex, 24, boulevard du Montparnasse, 75015 Paris, France; APHP, Hôpital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, 149, Rue de Sèvres, 75015 Paris, France.

Camille Roussel (C)

Université de Paris, Biologie Intégrée du Globule Rouge, UMR_S1134, BIGR, INSERM, F-75015 Paris, France; Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75015 Paris, France; Laboratoire d'Excellence Gr-Ex, 24, boulevard du Montparnasse, 75015 Paris, France.

Mario Carucci (M)

Université de Paris, Biologie Intégrée du Globule Rouge, UMR_S1134, BIGR, INSERM, F-75015 Paris, France; Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75015 Paris, France; Laboratoire d'Excellence Gr-Ex, 24, boulevard du Montparnasse, 75015 Paris, France.

Valentine Brousse (V)

Université de Paris, Biologie Intégrée du Globule Rouge, UMR_S1134, BIGR, INSERM, F-75015 Paris, France; Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75015 Paris, France; Laboratoire d'Excellence Gr-Ex, 24, boulevard du Montparnasse, 75015 Paris, France.

Papa Alioune Ndour (PA)

Université de Paris, Biologie Intégrée du Globule Rouge, UMR_S1134, BIGR, INSERM, F-75015 Paris, France; Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75015 Paris, France; Laboratoire d'Excellence Gr-Ex, 24, boulevard du Montparnasse, 75015 Paris, France.

Pierre Buffet (P)

Université de Paris, Biologie Intégrée du Globule Rouge, UMR_S1134, BIGR, INSERM, F-75015 Paris, France; Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75015 Paris, France; Laboratoire d'Excellence Gr-Ex, 24, boulevard du Montparnasse, 75015 Paris, France; APHP, Hôpital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, 149, Rue de Sèvres, 75015 Paris, France. Electronic address: pabuffet@gmail.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Érythrocytes › The Human Spleen in Malaria: Filter or Shelter?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Human Spleen in Malaria: Filter or Shelter?
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › The Human Spleen in Malaria: Filter or Shelter?
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › The Human Spleen in Malaria: Filter or Shelter?
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › The Human Spleen in Malaria: Filter or Shelter?