Th1-Th2 Cross-Regulation Controls Early Leishmania Infection in the Skin by Modulating the Size of the Permissive Monocytic Host Cell Reservoir.

Animals Female Interferon-gamma / deficiency Interleukin-10 / deficiency Leishmaniasis / immunology Macrophages / immunology Mice Mice, Inbred C57BL / genetics Mice, Knockout Monocytes / immunology Permissiveness Psychodidae Receptors, CCR2 / deficiency STAT6 Transcription Factor / deficiency Skin / immunology Th1 Cells / immunology Th2 Cells / immunology Virus Replication
CCR2 IFN-γ IL-10 Leishmania STAT6 Th1 Th2 iNOS monocytes

Journal

Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316

Informations de publication

Date de publication:
13 05 2020
Historique:
received: 23 09 2019
revised: 13 01 2020
accepted: 16 03 2020
pubmed: 17 4 2020
medline: 20 1 2021
entrez: 17 4 2020
Statut: ppublish

Résumé

The impact of T helper (Th) 1 versus Th2 immunity on intracellular infections is attributed to classical versus alternative activation of macrophages leading to resistance or susceptibility. However, observations in multiple infectious settings demonstrate deficiencies in mediators of Th1-Th2 immunity, which have paradoxical or no impact. We report that prior to influencing activation, Th1/Th2 immunity first controls the size of the permissive host cell reservoir. During early Leishmania infection of the skin, IFN-γ- or STAT6-mediated changes in phagocyte activation were counteracted by changes in IFN-γ-mediated recruitment of permissive CCR2

Identifiants

DOI: 10.1016/j.chom.2020.03.011 PMID: 32298657
pubmed: 32298657
pii: S1931-3128(20)30175-X
doi: 10.1016/j.chom.2020.03.011
pii:
doi:

Substances chimiques

Ccr2 protein, mouse 0
IL10 protein, mouse 0
Receptors, CCR2 0
STAT6 Transcription Factor 0
Interleukin-10 130068-27-8
Interferon-gamma 82115-62-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

752-768.e7

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Matheus Batista Carneiro (MB)

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.

Mateus Eustáquio Lopes (ME)

Departamento de Bioquímica e Imunologia - ICB - Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270901, Brazil.

Leah S Hohman (LS)

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.

Audrey Romano (A)

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Bruna Araujo David (BA)

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4Z6, Canada.

Rachel Kratofil (R)

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4Z6, Canada.

Paul Kubes (P)

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4Z6, Canada.

Matthew L Workentine (ML)

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.

Alexandre C Campos (AC)

Departamento de Bioquímica e Imunologia - ICB - Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270901, Brazil.

Leda Quercia Vieira (LQ)

Departamento de Bioquímica e Imunologia - ICB - Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270901, Brazil.

Nathan C Peters (NC)

Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada. Electronic address: ncpeters@ucalgary.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Infections de la peau › Dermatoses parasitaires › Leishmaniose › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement social › Permissivité › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Psychodidae › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CCR › Récepteurs CCR2 › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-6 › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Système tégumentaire › Peau › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th2 › Th1-Th2 Cross-Regulation Controls Early...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Th1-Th2 Cross-Regulation Controls Early...