Demineralized bone matrix paste formulated with biomimetic PLGA microcarriers for the vancomycin hydrochloride controlled delivery: Release profile, citotoxicity and efficacy against S. aureus.
Anti-Bacterial Agents
/ chemistry
Biomimetic Materials
Bone Demineralization Technique
Bone Matrix
/ chemistry
Cell Survival
/ drug effects
Cells, Cultured
Delayed-Action Preparations
Drug Carriers
Drug Compounding
Drug Liberation
Durapatite
/ chemistry
Humans
Kinetics
Microbial Sensitivity Tests
Particle Size
Polylactic Acid-Polyglycolic Acid Copolymer
/ chemistry
Staphylococcus aureus
/ drug effects
Vancomycin
/ chemistry
Controlled delivery
Cytotoxicity
Demineralized bone matrix
PLGA microcarrier
Staphylococcus aureus
Vancomycin hydrochloride
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 May 2020
30 May 2020
Historique:
received:
10
12
2019
revised:
07
04
2020
accepted:
08
04
2020
pubmed:
17
4
2020
medline:
20
2
2021
entrez:
17
4
2020
Statut:
ppublish
Résumé
Infection and resulting bone defects caused by Staphylococcus aureus is one of the major issues in orthopaedic surgeries. Vancomycin hydrochloride (VaH) is largely used to manage these events. Here, a human derived bone paste supplemented with biopolymer microcarriers for VaH sustained delivery to merge osteoinductive and antimicrobial actions is described. In detail, different emulsion formulations were tested to fabricate micro-carriers of poly-lactic-co-glycolic acid (PLGA) and hydroxyapatite (HA) by a proprietary technology (named Supercritical Emulsion Extraction). These carriers (mean size 827 ± 68 μm; loading 47 mg
Identifiants
pubmed: 32298742
pii: S0378-5173(20)30306-9
doi: 10.1016/j.ijpharm.2020.119322
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Delayed-Action Preparations
0
Drug Carriers
0
Polylactic Acid-Polyglycolic Acid Copolymer
1SIA8062RS
Vancomycin
6Q205EH1VU
Durapatite
91D9GV0Z28
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119322Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.