A novel exopolysaccharide from marine bacterium Pantoea sp. YU16-S3 accelerates cutaneous wound healing through Wnt/β-catenin pathway.
Animals
Cell Line
Extracellular Polymeric Substance Matrix
/ chemistry
Fibroblasts
/ drug effects
Humans
Keratinocytes
/ drug effects
Mice
Pantoea
/ chemistry
Polysaccharides, Bacterial
/ chemistry
Rats
Rats, Wistar
Skin
/ drug effects
Wnt Signaling Pathway
Wound Healing
/ drug effects
beta Catenin
/ metabolism
Biomaterial
Exopolysaccharide
Pantoea sp.
Re-epithelialization
Wound healing
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
15 Jun 2020
15 Jun 2020
Historique:
received:
02
07
2019
revised:
03
03
2020
accepted:
17
03
2020
entrez:
18
4
2020
pubmed:
18
4
2020
medline:
7
1
2021
Statut:
ppublish
Résumé
Natural polysaccharides with versatile properties are the potential candidates for wound healing applications. In this study, an exopolysaccharide, EPS-S3, isolated from a marine bacteria Pantoea sp. YU16-S3 was evaluated for its wound-healing abilities by studying the key molecular mechanisms in vitro and in vivo. Basic characterisation showed EPS-S3 as a heteropolysaccharide with glucose, galactose, N-acetyl galactosamine and glucosamine. The molecular weight of EPS-S3 was estimated to be 1.75 × 10
Identifiants
pubmed: 32299547
pii: S0144-8617(20)30365-9
doi: 10.1016/j.carbpol.2020.116191
pii:
doi:
Substances chimiques
Ctnnb1 protein, rat
0
Polysaccharides, Bacterial
0
beta Catenin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
116191Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.