Hyperacute Management of Ischemic Strokes: JACC Focus Seminar.
Algorithms
Anesthesia, General
Arterial Occlusive Diseases
/ complications
Clinical Trials as Topic
Conscious Sedation
Contraindications, Drug
Fibrinolytic Agents
/ therapeutic use
Hemodynamics
Humans
Intracranial Arteriosclerosis
/ complications
Ischemic Stroke
/ etiology
Neuroimaging
Practice Guidelines as Topic
Thrombectomy
Time-to-Treatment
Tissue Plasminogen Activator
/ therapeutic use
Triage
IV-rtPA
acute ischemic stroke
imaging in acute stroke
mechanical thrombectomy
mechanical thrombectomy in extended time window
Journal
Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
received:
07
02
2020
revised:
03
03
2020
accepted:
06
03
2020
entrez:
18
4
2020
pubmed:
18
4
2020
medline:
29
12
2020
Statut:
ppublish
Résumé
Acute ischemic stroke is the leading cause of disability and among the leading causes of mortality worldwide. Intravenous tissue plasminogen activator has been a cornerstone for treatment of acute ischemic stroke for more than 20 years; however, its use is limited due to a narrow therapeutic window, several contraindications, and low efficacy to recanalize the artery in large vessel occlusion. Recently, the addition of endovascular mechanical thrombectomy of large artery occlusion has revolutionized the stroke treatment for most disabling strokes. The paper reviews updates to the thrombolytic treatment as well as catheter-based treatment, and results from recent trials in the selection of patients in an extended time window using perfusion imaging.
Identifiants
pubmed: 32299596
pii: S0735-1097(20)34490-9
doi: 10.1016/j.jacc.2020.03.006
pii:
doi:
Substances chimiques
Fibrinolytic Agents
0
Tissue Plasminogen Activator
EC 3.4.21.68
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1844-1856Informations de copyright
Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.