Should we expect neurological symptoms in the SARS-CoV-2 epidemic?
¿Es esperable que haya cuadros neurológicos por la pandemia por SARS-CoV-2?
Central nervous system
Coronavirus
Esclerosis múltiple
MERS-CoV
Mouse hepatitis virus
Multiple sclerosis
Neurological symptoms
SARS-CoV
SARS-CoV-2
Sistema nervioso central
Síntomas neurológicos
Virus murino de la hepatitis
Journal
Neurologia
ISSN: 2173-5808
Titre abrégé: Neurologia (Engl Ed)
Pays: Spain
ID NLM: 101778590
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
27
03
2020
accepted:
31
03
2020
pubmed:
18
4
2020
medline:
6
5
2020
entrez:
18
4
2020
Statut:
ppublish
Résumé
There is growing evidence that SARS-CoV-2 can gain access to the central nervous system (CNS). We revise the literature on coronavirus infection of the CNS associated with neurological diseases. Neurological symptoms were rarely reported in the SARS-CoV and MERS-CoV epidemics, although isolated cases were described. There are also reports of cases of neurological symptoms associated with CoV-OC43 and CoV-229E infection. The presence of neurological lesions, especially demyelinating lesions in the mouse hepatitis virus model, may explain the mechanisms by which coronaviruses enter the CNS, particularly those related with the immune response. This may explain the presence of coronavirus in patients with multiple sclerosis. We review the specific characteristics of SARS-CoV-2 and address the question of whether the high number of cases may be associated with greater CNS involvement. Although neurological symptoms are not frequent in coronavirus epidemics, the high number of patients with SARS-CoV-2 infection may explain the presence of the virus in the CNS and increase the likelihood of early- or delayed-onset neurological symptoms. Follow-up of patients affected by the SARS-CoV-2 epidemic should include careful assessment of the CNS.
Identifiants
pubmed: 32299636
pii: S0213-4853(20)30065-7
doi: 10.1016/j.nrl.2020.03.001
pmc: PMC7136883
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
170-175Informations de copyright
Copyright © 2020 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.
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