Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma.

Adenosine Triphosphate Animals Asthma Cell Communication Guinea Pigs Muscle Contraction Muscle, Smooth TRPV Cation Channels

Journal

The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460

Informations de publication

Date de publication:
07 2020
Historique:
received: 22 07 2019
accepted: 27 02 2020
pubmed: 18 4 2020
medline: 22 6 2021
entrez: 18 4 2020
Statut: epublish

Résumé

Mast cell-airway smooth muscle (ASM) interactions play a major role in the immunoglobulin (Ig)E- dependent bronchoconstriction seen in asthma but less is known about IgE-independent mechanisms of mast cell activation. Transient receptor potential cation channel, subfamily V, member 4 (TRPV4) activation causes contraction of human ASM

Identifiants

DOI: 10.1183/13993003.01458-2019 PMID: 32299856 PMC: PMC7330131
pubmed: 32299856
pii: 13993003.01458-2019
doi: 10.1183/13993003.01458-2019
pmc: PMC7330131
pii:
doi:

Substances chimiques

TRPV Cation Channels 0
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207504/B/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K020293/1
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright ©ERS 2020.

Déclaration de conflit d'intérêts

Conflict of interest: S.J. Bonvini is employed by AstraZeneca. Conflict of interest: M.A. Birrell is employed by AstraZeneca and was a non-executive director of an Imperial College spinout contract research company engaged in respiratory pre-clinical work. Conflict of interest: E. Dubuis has nothing to disclose. Conflict of interest: J.J. Adcock is employed by AstraZeneca. Conflict of interest: M.A. Wortley has nothing to disclose. Conflict of interest: P. Flajolet has nothing to disclose. Conflict of interest: P. Bradding has nothing to disclose. Conflict of interest: M.G. Belvisi reports grants from Wellcome Trust and Medical Research Council, during the conduct of the study; is employed by AstraZeneca and was a non-executive director of an Imperial College spinout contract research company engaged in respiratory pre-clinical work, and has been a consultant for Ario Pharma, Aboca, Patara, NeRRe, MedImmune and Boehringer Ingelheim.

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Auteurs

Sara J Bonvini (SJ)

Respiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Contributed equally.

Mark A Birrell (MA)

Respiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Contributed equally.

Eric Dubuis (E)

Respiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.

John J Adcock (JJ)

Respiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.
Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Michael A Wortley (MA)

Respiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.

Pauline Flajolet (P)

Respiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK.

Peter Bradding (P)

Dept of Infection, Immunity and Inflammation, University of Leicester University, Institute for Lung Health, Glenfield Hospital, Leicester, UK.

Maria G Belvisi (MG)

Respiratory Pharmacology Group, Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK m.belvisi@imperial.ac.uk.
Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Novel airway smooth muscle-mast cell...
questionsmedicales.fr › Eucaryotes › Animaux › Novel airway smooth muscle-mast cell...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Novel airway smooth muscle-mast cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › Novel airway smooth muscle-mast cell...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Novel airway smooth muscle-mast cell...