Daily exposure to formaldehyde and acetaldehyde and potential health risk associated with use of high and low nicotine e-liquid concentrations.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
16 04 2020
16 04 2020
Historique:
received:
14
06
2019
accepted:
25
03
2020
entrez:
18
4
2020
pubmed:
18
4
2020
medline:
26
11
2020
Statut:
epublish
Résumé
Recent evidence suggests that e-cigarette users tend to change their puffing behaviors when using e-liquids with reduced nicotine concentrations by taking longer and more frequent puffs. Using puffing regimens modelled on puffing topography data from 19 experienced e-cigarette users who switched between 18 and 6 mg/mL e-liquids with and without power adjustments, differences in daily exposure to carbonyl compounds and estimated changes in cancer risk were assessed by production of aerosols generated using a smoking machine and analyzed using gas and liquid chromatography. Significant differences across conditions were found for formaldehyde and acetaldehyde (p < 0.01). Switching from a higher to a lower nicotine concentration was associated with greater exposure regardless of whether power settings were fixed or adjustable which is likely due to increased liquid consumption under lower nicotine concentration settings. Daily exposure for formaldehyde and acetaldehyde was higher for 17/19 participants when using low (6 mg/mL) compared with high (18 mg/mL) nicotine e-liquid concentration when power was fixed. When power adjustments were permitted, formaldehyde and acetaldehyde levels were higher respectively for 16/19 and 14/19 participants with the use of 6 compared with 18 mg/mL nicotine e-liquid.
Identifiants
pubmed: 32300142
doi: 10.1038/s41598-020-63292-1
pii: 10.1038/s41598-020-63292-1
pmc: PMC7162853
doi:
Substances chimiques
Aerosols
0
Carcinogens
0
Formaldehyde
1HG84L3525
Nicotine
6M3C89ZY6R
Acetaldehyde
GO1N1ZPR3B
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6546Subventions
Organisme : Cancer Research UK (CRUK)
ID : C50878/A21130
Pays : International
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