Evaluation of the optic nerve head vessel density in the patients with asymmetric pseudoexfoliative glaucoma: an OCT angiography study.
Cross-Sectional Studies
Exfoliation Syndrome
/ diagnosis
Female
Fluorescein Angiography
/ methods
Follow-Up Studies
Fundus Oculi
Humans
Male
Microvascular Density
Middle Aged
Optic Disk
/ blood supply
Prospective Studies
Retinal Vessels
/ pathology
Tomography, Optical Coherence
/ methods
Visual Fields
Optic nerve perfusion
Optical coherence tomography angiography
Peripapillary vessel density
Pseudoexfoliation syndrome
Pseudoexfoliative glaucoma
Journal
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
ISSN: 1435-702X
Titre abrégé: Graefes Arch Clin Exp Ophthalmol
Pays: Germany
ID NLM: 8205248
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
27
12
2019
accepted:
27
03
2020
revised:
22
03
2020
pubmed:
18
4
2020
medline:
14
4
2021
entrez:
18
4
2020
Statut:
ppublish
Résumé
To evaluate vascular microcirculation changes of the optic nerve head (ONH) in the patients with asymmetric pseudoexfoliative glaucoma (XFG) using optical coherence tomography angiography (OCTA) and to compare vessel density (VD) results with healthy individuals. This prospective study enrolled 120 eyes in total. The eyes were divided into 3 groups: 40 glaucomatous and 40 non-glaucomatous fellow eyes without clinically pseudoexfoliation material (XFM) of patients with asymmetric XFG, and 40 healthy eyes as controls. The optic disc region was evaluated with OCTA (Optovue, Inc., Fremont, CA). VD was assessed as the ratio of the area formed by the vessels in 3 different regions: (1) inside disc; (2) in the peripapillary area defined as a 1-mm wide elliptical annulus around the disc; and (3) in the whole image defined as a 4-mm wide papillary region. There were significant decreases in VD values of all regions in XFG eyes compared to fellow and control eyes (p < 0.05 for all comparisons). The mean VD values of peripapillary area and whole image were lower in the non-glaucomatous fellow eyes compared with control eyes (p = 0.011 and p = 0.015, respectively). The receiver operating characteristic analysis for differentiating fellow eyes from healthy eyes had highest area under the curve and sensitivity at 90% specificity for superior-hemi (0.811, 65.2%), followed by ppVD (0.775, 61.8%) and whole image (0.743, 55.9%). OCTA as a novel imaging may be a valuable structural test in diagnosis and follow-up of glaucoma.
Identifiants
pubmed: 32300958
doi: 10.1007/s00417-020-04668-x
pii: 10.1007/s00417-020-04668-x
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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