Drug repositioning: a brief overview.
drug
generic
indication
repositioning
Journal
The Journal of pharmacy and pharmacology
ISSN: 2042-7158
Titre abrégé: J Pharm Pharmacol
Pays: England
ID NLM: 0376363
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
14
02
2020
revised:
17
03
2020
accepted:
21
03
2020
pubmed:
18
4
2020
medline:
29
5
2021
entrez:
18
4
2020
Statut:
ppublish
Résumé
Drug repositioning, that is, the use of a drug in an indication other than the one for which it was initially marketed, is a growing trend. Its origins lie mainly in the attrition experienced in recent years in the field of new drug discovery. Despite some regulatory and economic challenges, drug repositioning offers many advantages, and a number of recent successes have confirmed both its public health benefits and its commercial value. The first examples of successful drug repositioning mainly came about through serendipity like acetylsalicylic acid, thalidomide, sildenafil or dimethylfumarate. The history of great-repositioned drugs has given some solutions to various pathologies. Serendipity is not yet useful to find repositioning drugs. Drug repositioning is of growing interest. Nowadays, a more rational approach to the identification of drug candidates for repositioning is possible, especially using data mining.
Identifiants
pubmed: 32301512
doi: 10.1111/jphp.13273
pmc: PMC7262062
doi:
Types de publication
Historical Article
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1145-1151Informations de copyright
© 2020 Royal Pharmaceutical Society.
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