Citral inhibits N-nitrosodiethylamine-induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic-metabolizing enzymes.
Acyclic Monoterpenes
/ therapeutic use
Animals
Antineoplastic Agents, Phytogenic
/ therapeutic use
Antioxidants
/ metabolism
Carcinoembryonic Antigen
/ analysis
Carcinoma, Hepatocellular
/ drug therapy
Cell Line, Tumor
Diethylnitrosamine
Humans
Liver Function Tests
Liver Neoplasms, Experimental
/ drug therapy
Male
Proliferating Cell Nuclear Antigen
/ metabolism
Rats
Rats, Wistar
alpha-Fetoproteins
/ analysis
N-nitrosodiethylamine
ROS
citral
serum tumor marker enzymes
xenobiotic enzymes
Journal
Environmental toxicology
ISSN: 1522-7278
Titre abrégé: Environ Toxicol
Pays: United States
ID NLM: 100885357
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
22
11
2019
revised:
02
04
2020
accepted:
04
04
2020
pubmed:
18
4
2020
medline:
9
9
2020
entrez:
18
4
2020
Statut:
ppublish
Résumé
Hepatocellular carcinoma (HCC) ranks the sixth position among various cancers worldwide. Recent research shows that natural and dietary compounds possess many therapeutic effects. Citral is a monoterpene aldehyde that contains geranial and neral. The present study was considered to study the role of citral against N-nitrosodiethylamine (NDEA)-induced HCC via modulation of antioxidants and xenobiotic-metabolizing enzymes in vivo. NDEA-alone-administered group II animals profoundly showed increased tumor incidence, reactive oxygen species, liver marker enzyme levels, serum bilirubin levels, tumor markers of carcinoembryonic antigen, α-fetoprotein, proliferative markers of argyrophilic nucleolar organizing regions, proliferating cell nuclear antigen (PCNA) expressions, phase I xenobiotic-metabolic enzymes and simultaneously decreased antioxidants, and phase II enzymes levels. Citral (100 mg/kg b.w.) treatment significantly reverted the levels in group III cancer-bearing animals when compared to group II cancer-bearing animals. In group IV animals, citral-alone administration did not produce any adverse effect during the experimental condition. Based on the results, citral significantly inhibits the hepatocellular carcinogenesis through restoring the antioxidants and phase II xenobiotic-enzyme levels; thereby, it strongly proves as an antiproliferative agent against rat HCC.
Substances chimiques
Acyclic Monoterpenes
0
Antineoplastic Agents, Phytogenic
0
Antioxidants
0
Carcinoembryonic Antigen
0
Proliferating Cell Nuclear Antigen
0
alpha-Fetoproteins
0
Diethylnitrosamine
3IQ78TTX1A
citral
T7EU0O9VPP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
971-981Informations de copyright
© 2020 Wiley Periodicals, Inc.
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