Intranasal epinephrine in dogs: Pharmacokinetic and heart rate effects.
administration
anaphylaxis
epinephrine
intranasal
nasal absorption
pharmacokinetics
Journal
Pharmacology research & perspectives
ISSN: 2052-1707
Titre abrégé: Pharmacol Res Perspect
Pays: United States
ID NLM: 101626369
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
24
02
2020
revised:
09
03
2020
accepted:
11
03
2020
entrez:
18
4
2020
pubmed:
18
4
2020
medline:
7
4
2021
Statut:
ppublish
Résumé
Epinephrine is the standard of care for the treatment of severe allergy and anaphylaxis. Epinephrine is most often administered through the intramuscular (IM) route via autoinjector. The current study aimed to evaluate an alternative method of epinephrine treatment through intranasal (IN) delivery in dogs. The pharmacokinetic (PK) parameters of maximum plasma concentration (C
Identifiants
pubmed: 32302068
doi: 10.1002/prp2.587
pmc: PMC7164403
doi:
Substances chimiques
Bronchodilator Agents
0
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e00587Informations de copyright
© 2020 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.
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