The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.
AI
Cancer Moonshot
Human Tumor Atlas
cancer transitions
data integration
data visualization
metastasis
pre-cancer
resistance
single-cell genomics
spatial genomics
spatial imaging
tumor
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
16 04 2020
16 04 2020
Historique:
received:
18
12
2019
revised:
24
03
2020
accepted:
24
03
2020
entrez:
18
4
2020
pubmed:
18
4
2020
medline:
24
11
2020
Statut:
ppublish
Résumé
Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer.
Identifiants
pubmed: 32302568
pii: S0092-8674(20)30346-9
doi: 10.1016/j.cell.2020.03.053
pmc: PMC7376497
mid: NIHMS1587971
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
236-249Subventions
Organisme : NCI NIH HHS
ID : U24 CA233243
Pays : United States
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ID : U01 CA235482
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Organisme : Howard Hughes Medical Institute
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ID : T32 CA207021
Pays : United States
Investigateurs
Denise Aberle
(D)
Samuel I Achilefu
(SI)
Foluso O Ademuyiwa
(FO)
Andrew C Adey
(AC)
Rebecca L Aft
(RL)
Rachana Agarwal
(R)
Ruben A Aguilar
(RA)
Fatemeh Alikarami
(F)
Viola Allaj
(V)
Christopher Amos
(C)
Robert A Anders
(RA)
Michael R Angelo
(MR)
Kristen Anton
(K)
Orr Ashenberg
(O)
Jon C Aster
(JC)
Ozgun Babur
(O)
Amir Bahmani
(A)
Akshay Balsubramani
(A)
David Barrett
(D)
Jennifer Beane
(J)
Diane E Bender
(DE)
Kathrin Bernt
(K)
Lynne Berry
(L)
Courtney B Betts
(CB)
Julie Bletz
(J)
Katie Blise
(K)
Adrienne Boire
(A)
Genevieve Boland
(G)
Alexander Borowsky
(A)
Kristopher Bosse
(K)
Matthew Bott
(M)
Ed Boyden
(E)
James Brooks
(J)
Raphael Bueno
(R)
Erik A Burlingame
(EA)
Qiuyin Cai
(Q)
Joshua Campbell
(J)
Wagma Caravan
(W)
Ethan Cerami
(E)
Hassan Chaib
(H)
Joseph M Chan
(JM)
Young Hwan Chang
(YH)
Deyali Chatterjee
(D)
Ojasvi Chaudhary
(O)
Alyce A Chen
(AA)
Bob Chen
(B)
Changya Chen
(C)
Chia-Hui Chen
(CH)
Feng Chen
(F)
Yu-An Chen
(YA)
Milan G Chheda
(MG)
Koei Chin
(K)
Roxanne Chiu
(R)
Shih-Kai Chu
(SK)
Rodrigo Chuaqui
(R)
Jaeyoung Chun
(J)
Luis Cisneros
(L)
Robert J Coffey
(RJ)
Graham A Colditz
(GA)
Kristina Cole
(K)
Natalie Collins
(N)
Kevin Contrepois
(K)
Lisa M Coussens
(LM)
Allison L Creason
(AL)
Daniel Crichton
(D)
Christina Curtis
(C)
Tanja Davidsen
(T)
Sherri R Davies
(SR)
Ino de Bruijn
(I)
Laura Dellostritto
(L)
Angelo De Marzo
(A)
Emek Demir
(E)
David G DeNardo
(DG)
Dinh Diep
(D)
Li Ding
(L)
Sharon Diskin
(S)
Xengie Doan
(X)
Julia Drewes
(J)
Stephen Dubinett
(S)
Michael Dyer
(M)
Jacklynn Egger
(J)
Jennifer Eng
(J)
Barbara Engelhardt
(B)
Graham Erwin
(G)
Edward D Esplin
(ED)
Laura Esserman
(L)
Alex Felmeister
(A)
Heidi S Feiler
(HS)
Ryan C Fields
(RC)
Stephen Fisher
(S)
Keith Flaherty
(K)
Jennifer Flournoy
(J)
James M Ford
(JM)
Angelo Fortunato
(A)
Allison Frangieh
(A)
Jennifer L Frye
(JL)
Robert S Fulton
(RS)
Danielle Galipeau
(D)
Siting Gan
(S)
Jianjiong Gao
(J)
Long Gao
(L)
Peng Gao
(P)
Vianne R Gao
(VR)
Tim Geiger
(T)
Ajit George
(A)
Gad Getz
(G)
Sharmistha Ghosh
(S)
Marios Giannakis
(M)
David L Gibbs
(DL)
William E Gillanders
(WE)
Jeremy Goecks
(J)
Simon P Goedegebuure
(SP)
Alanna Gould
(A)
Kate Gowers
(K)
Joe W Gray
(JW)
William Greenleaf
(W)
Jeremy Gresham
(J)
Jennifer L Guerriero
(JL)
Tuhin K Guha
(TK)
Alexander R Guimaraes
(AR)
Justin Guinney
(J)
David Gutman
(D)
Nir Hacohen
(N)
Sean Hanlon
(S)
Casey R Hansen
(CR)
Olivier Harismendy
(O)
Kathleen A Harris
(KA)
Aaron Hata
(A)
Akimasa Hayashi
(A)
Cody Heiser
(C)
Karla Helvie
(K)
John M Herndon
(JM)
Gilliam Hirst
(G)
Frank Hodi
(F)
Travis Hollmann
(T)
Aaron Horning
(A)
James J Hsieh
(JJ)
Shannon Hughes
(S)
Won Jae Huh
(WJ)
Stephen Hunger
(S)
Shelley E Hwang
(SE)
Christine A Iacobuzio-Donahue
(CA)
Heba Ijaz
(H)
Benjamin Izar
(B)
Connor A Jacobson
(CA)
Samuel Janes
(S)
Judit Jané-Valbuena
(J)
Reyka G Jayasinghe
(RG)
Lihua Jiang
(L)
Brett E Johnson
(BE)
Bruce Johnson
(B)
Tao Ju
(T)
Humam Kadara
(H)
Klaus Kaestner
(K)
Jacob Kagan
(J)
Lukas Kalinke
(L)
Robert Keith
(R)
Aziz Khan
(A)
Warren Kibbe
(W)
Albert H Kim
(AH)
Erika Kim
(E)
Junhyong Kim
(J)
Annette Kolodzie
(A)
Mateusz Kopytra
(M)
Eran Kotler
(E)
Robert Krueger
(R)
Kostyantyn Krysan
(K)
Anshul Kundaje
(A)
Uri Ladabaum
(U)
Blue B Lake
(BB)
Huy Lam
(H)
Rozelle Laquindanum
(R)
Ken S Lau
(KS)
Ashley M Laughney
(AM)
Hayan Lee
(H)
Marc Lenburg
(M)
Carina Leonard
(C)
Ignaty Leshchiner
(I)
Rochelle Levy
(R)
Jerry Li
(J)
Christine G Lian
(CG)
Kian-Huat Lim
(KH)
Jia-Ren Lin
(JR)
Yiyun Lin
(Y)
Qi Liu
(Q)
Ruiyang Liu
(R)
Tracy Lively
(T)
William J R Longabaugh
(WJR)
Teri Longacre
(T)
Cynthia X Ma
(CX)
Mary Catherine Macedonia
(MC)
Tyler Madison
(T)
Christopher A Maher
(CA)
Anirban Maitra
(A)
Netta Makinen
(N)
Danika Makowski
(D)
Carlo Maley
(C)
Zoltan Maliga
(Z)
Diego Mallo
(D)
John Maris
(J)
Nick Markham
(N)
Jeffrey Marks
(J)
Daniel Martinez
(D)
Robert J Mashl
(RJ)
Ignas Masilionais
(I)
Jennifer Mason
(J)
Joan Massagué
(J)
Pierre Massion
(P)
Marissa Mattar
(M)
Richard Mazurchuk
(R)
Linas Mazutis
(L)
Sarah A Mazzilli
(SA)
Eliot T McKinley
(ET)
Joshua F McMichael
(JF)
Daniel Merrick
(D)
Matthew Meyerson
(M)
Julia R Miessner
(JR)
Gordon B Mills
(GB)
Meredith Mills
(M)
Suman B Mondal
(SB)
Motomi Mori
(M)
Yuriko Mori
(Y)
Elizabeth Moses
(E)
Yael Mosse
(Y)
Jeremy L Muhlich
(JL)
George F Murphy
(GF)
Nicholas E Navin
(NE)
Tal Nawy
(T)
Michel Nederlof
(M)
Reid Ness
(R)
Stephanie Nevins
(S)
Milen Nikolov
(M)
Ajit Johnson Nirmal
(AJ)
Garry Nolan
(G)
Edward Novikov
(E)
Philipp Oberdoerffer
(P)
Brendan O'Connell
(B)
Michael Offin
(M)
Stephen T Oh
(ST)
Anastasiya Olson
(A)
Alex Ooms
(A)
Miguel Ossandon
(M)
Kouros Owzar
(K)
Swapnil Parmar
(S)
Tasleema Patel
(T)
Gary J Patti
(GJ)
Dana Pe'er
(D)
Itsik Pe'er
(I)
Tao Peng
(T)
Daniel Persson
(D)
Marvin Petty
(M)
Hanspeter Pfister
(H)
Kornelia Polyak
(K)
Kamyar Pourfarhangi
(K)
Sidharth V Puram
(SV)
Qi Qiu
(Q)
Álvaro Quintanal-Villalonga
(Á)
Arjun Raj
(A)
Marisol Ramirez-Solano
(M)
Rumana Rashid
(R)
Ashley N Reeb
(AN)
Aviv Regev
(A)
Mary Reid
(M)
Adam Resnick
(A)
Sheila M Reynolds
(SM)
Jessica L Riesterer
(JL)
Scott Rodig
(S)
Joseph T Roland
(JT)
Sonia Rosenfield
(S)
Asaf Rotem
(A)
Sudipta Roy
(S)
Orit Rozenblatt-Rosen
(O)
Charles M Rudin
(CM)
Marc D Ryser
(MD)
Sandro Santagata
(S)
Maria Santi-Vicini
(M)
Kazuhito Sato
(K)
Denis Schapiro
(D)
Deborah Schrag
(D)
Nikolaus Schultz
(N)
Cynthia L Sears
(CL)
Rosalie C Sears
(RC)
Subrata Sen
(S)
Triparna Sen
(T)
Alex Shalek
(A)
Jeff Sheng
(J)
Quanhu Sheng
(Q)
Kooresh I Shoghi
(KI)
Martha J Shrubsole
(MJ)
Yu Shyr
(Y)
Alexander B Sibley
(AB)
Kiara Siex
(K)
Alan J Simmons
(AJ)
Dinah S Singer
(DS)
Shamilene Sivagnanam
(S)
Michal Slyper
(M)
Michael P Snyder
(MP)
Artem Sokolov
(A)
Sheng-Kwei Song
(SK)
Peter K Sorger
(PK)
Austin Southard-Smith
(A)
Avrum Spira
(A)
Sudhir Srivastava
(S)
Janet Stein
(J)
Phillip Storm
(P)
Elizabeth Stover
(E)
Siri H Strand
(SH)
Timothy Su
(T)
Damir Sudar
(D)
Ryan Sullivan
(R)
Lea Surrey
(L)
Mario Suvà
(M)
Kai Tan
(K)
Nadezhda V Terekhanova
(NV)
Luke Ternes
(L)
Lisa Thammavong
(L)
Guillaume Thibault
(G)
George V Thomas
(GV)
Vésteinn Thorsson
(V)
Ellen Todres
(E)
Linh Tran
(L)
Madison Tyler
(M)
Yasin Uzun
(Y)
Anil Vachani
(A)
Eliezer Van Allen
(E)
Simon Vandekar
(S)
Deborah J Veis
(DJ)
Sébastien Vigneau
(S)
Arastoo Vossough
(A)
Angela Waanders
(A)
Nikhil Wagle
(N)
Liang-Bo Wang
(LB)
Michael C Wendl
(MC)
Robert West
(R)
Elizabeth H Williams
(EH)
Chi-Yun Wu
(CY)
Hao Wu
(H)
Hung-Yi Wu
(HY)
Matthew A Wyczalkowski
(MA)
Yubin Xie
(Y)
Xiaolu Yang
(X)
Clarence Yapp
(C)
Wenbao Yu
(W)
Yinyin Yuan
(Y)
Dadong Zhang
(D)
Kun Zhang
(K)
Mianlei Zhang
(M)
Nancy Zhang
(N)
Yantian Zhang
(Y)
Yanyan Zhao
(Y)
Daniel Cui Zhou
(DC)
Zilu Zhou
(Z)
Houxiang Zhu
(H)
Qin Zhu
(Q)
Xiangzhu Zhu
(X)
Yuankun Zhu
(Y)
Xiaowei Zhuang
(X)
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Interests A.R. is a founder of and equity holder in Celsius Therapeutics, an equity holder in Immunitas Therapeutics, and a scientific advisory board (SAB) member of Syros Pharmaceuticals, ThermoFisher Scientific, Asimov, and NeoGene Therapeutics. A.K.S. has received compensation for consulting for and being on the SAB of Honeycomb Biotechnologies, Cellarity, Cogen Therapeutics, and Dahlia Biosciences. O.R.R., A.K.S., and A.R. are co-inventors on patent applications filed by the Broad Institute to inventions relating to single-cell genomics, such as in PCT/US2018/060860 and US provisional application no. 62/745,259. J.W.G. has licensed technologies to Abbott Diagnostics and Danaher and has ownership positions in PDX Pharmaceuticals and Convergent Genomics. He serves as an advisor to New Leaf Ventures and receives private-sector research support from Zeiss, ThermoFisher, Danaher, Micron, PDX Pharmaceuticals, and Quantitative Imaging. C.I.D. receives research support from Bristol-Myers Squibb. S.S. is a consultant for RareCyte, Inc. A.S. is an employee of Johnson & Johnson. S.A.M. has commercial research grants from Johnson & Johnson. P.K.S. is a member of the SAB or board of directors of and has equity in Glencoe Software and RareCyte Inc., which create software and instruments for tissue imaging.
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