Hv1/VSOP regulates neutrophil directional migration and ERK activity by tuning ROS production.
ERK
ROS
migration
proton channel
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
30
03
2019
revised:
04
03
2020
accepted:
05
03
2020
pubmed:
18
4
2020
medline:
5
11
2020
entrez:
18
4
2020
Statut:
ppublish
Résumé
High-level reactive oxygen species (ROS) production in neutrophils is tightly regulated, as it can damage host cells. Neutrophils also undergo low-level ROS production when stimulated by cytokines or chemoattractants, but its biologic significance remains largely unknown. Voltage-gated proton channels (Hv1/VSOP) activity reportedly supports ROS production in neutrophils; however, we show here that Hv1/VSOP balances ROS production to suppress neutrophil directional migration in the presence of low concentrations of N-formyl-Met-Leu-Phe (fMLF). Neutrophils derived from Hvcn1 gene knockout mice produced more ROS than neutrophils from wild-type mice in the stimulation with fMLF at concentration of 1 µM and nonstimulus condition. They also exhibited stronger chemotactic responses to low concentrations of fMLF than did wild-type neutrophils. Receptor sensitivity to fMLF and evoked Ca
Identifiants
pubmed: 32303121
doi: 10.1002/JLB.2A0320-110RR
doi:
Substances chimiques
Hv1 proton channel, mouse
0
Ion Channels
0
Reactive Oxygen Species
0
N-Formylmethionine Leucyl-Phenylalanine
59880-97-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
819-831Informations de copyright
©2020 Society for Leukocyte Biology.
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