The Outcome of
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
received:
24
11
2019
revised:
15
03
2020
accepted:
14
04
2020
pubmed:
19
4
2020
medline:
13
3
2021
entrez:
19
4
2020
Statut:
ppublish
Résumé
During our efforts to develop tumor-infiltrating lymphocyte (TIL) therapy to counter the devastating recurrence rate in patients with primary resectable pancreatic ductal adenocarcinoma (PDA), we found that PDA TILs can readily be expanded We compared the clonal composition of TIL preparations before and after We found that the TIL TCR repertoire changes dramatically during Culture-induced changes in clonal composition are likely to affect tumor reactivity of TIL preparations. TCR deep sequencing provides important insights into the factors that govern the outcome of
Identifiants
pubmed: 32303540
pii: 1078-0432.CCR-19-3845
doi: 10.1158/1078-0432.CCR-19-3845
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
4289-4301Commentaires et corrections
Type : CommentIn
Type : CommentOn
Informations de copyright
©2020 American Association for Cancer Research.