IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
17 04 2020
17 04 2020
Historique:
received:
12
09
2018
revised:
02
11
2019
accepted:
26
03
2020
entrez:
19
4
2020
pubmed:
19
4
2020
medline:
1
1
2021
Statut:
ppublish
Résumé
Dendritic cells play a key role in the orchestration of antitumor immune responses. The cDC1 (conventional dendritic cell 1) subset has been shown to be essential for antitumor responses and response to immunotherapy, but its precise role in humans is largely unexplored. Using a multidisciplinary approach, we demonstrate that human cDC1 play an important role in the antitumor immune response through their capacity to produce type III interferon (IFN-λ). By analyzing a large cohort of breast primary tumors and public transcriptomic datasets, we observed specific production of IFN-λ1 by cDC1. In addition, both IFN-λ1 and its receptor were associated with favorable patient outcomes. We show that IFN-III promotes a T
Identifiants
pubmed: 32303573
pii: 5/46/eaav3942
doi: 10.1126/sciimmunol.aav3942
pii:
doi:
Substances chimiques
Interferons
9008-11-1
Interferon Lambda
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.