Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Aging
Animals
Betacoronavirus
/ isolation & purification
COVID-19
Coronavirus Infections
/ pathology
Disease Models, Animal
Female
Lung
/ pathology
Macaca fascicularis
Middle East Respiratory Syndrome Coronavirus
/ isolation & purification
Pandemics
Pneumonia, Viral
/ pathology
Pulmonary Alveoli
/ pathology
Respiratory System
/ pathology
Severe acute respiratory syndrome-related coronavirus
/ isolation & purification
SARS-CoV-2
Severe Acute Respiratory Syndrome
/ pathology
Virus Replication
Virus Shedding
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
29 05 2020
29 05 2020
Historique:
received:
15
03
2020
accepted:
15
04
2020
pubmed:
19
4
2020
medline:
3
6
2020
entrez:
19
4
2020
Statut:
ppublish
Résumé
The current pandemic coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques and provides a new model to test preventive and therapeutic strategies.
Identifiants
pubmed: 32303590
pii: science.abb7314
doi: 10.1126/science.abb7314
pmc: PMC7164679
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1012-1015Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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