T-Cell Repertoire in Combination with T-Cell Density Predicts Clinical Outcomes in Patients with Merkel Cell Carcinoma.

Adult Aged Aged, 80 and over Carcinoma, Merkel Cell / immunology Female Humans Lymphatic Metastasis Male Middle Aged Neoplasm Staging Prognosis Receptors, Antigen, T-Cell / immunology Skin Neoplasms / immunology T-Lymphocytes / immunology

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
11 2020
Historique:
received: 17 09 2019
revised: 09 02 2020
accepted: 12 02 2020
pubmed: 19 4 2020
medline: 7 4 2021
entrez: 19 4 2020
Statut: ppublish

Résumé

The integrity of the immune system represents a pivotal risk factor and prognostic biomarker for Merkel cell carcinoma. A higher density of tumor-associated T cells correlates with improved Merkel cell carcinoma-specific survival, but the prognostic importance of the T-cell infiltrate reactivity is unknown. We evaluated the T-cell receptor repertoire associated with 72 primary Merkel cell carcinomas and correlated metrics of the T-cell receptor repertoire with clinicopathologic characteristics and patient outcomes. We showed that a high Simpson's Dominance index (SDom) was significantly associated with fewer metastases (P = 0.01), lower stage at presentation (P = 0.02), lower final stage at last follow-up (P = 0.05), and longer time to first lymph node metastasis (P = 0.04). These correlations were mostly preserved in the Merkel cell polyomavirus-negative subgroup. Combining SDom with CD3

Identifiants

DOI: 10.1016/j.jid.2020.02.031 PMID: 32304704
pubmed: 32304704
pii: S0022-202X(20)31355-5
doi: 10.1016/j.jid.2020.02.031
pii:
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2146-2156.e4

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Maya Farah (M)

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Alexandre Reuben (A)

Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Ivelina Spassova (I)

Translational Skin Cancer Research, University Clinic Essen, Essen, Germany.

Richard K Yang (RK)

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Linda Kubat (L)

Translational Skin Cancer Research, University Clinic Essen, Essen, Germany.

Priyadharsini Nagarajan (P)

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Jing Ning (J)

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Wen Li (W)

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Phyu P Aung (PP)

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Jonathan L Curry (JL)

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Carlos A Torres-Cabala (CA)

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Courtney W Hudgens (CW)

Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Selma Ugurel (S)

Department of Dermatology, University Clinic Essen, Essen, Germany.

Dirk Schadendorf (D)

Department of Dermatology, University Clinic Essen, Essen, Germany.

Curtis Gumbs (C)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Latasha D Little (LD)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Andrew Futreal (A)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Ignacio I Wistuba (II)

Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Victor G Prieto (VG)

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Linghua Wang (L)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Michael K Wong (MK)

Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Jennifer A Wargo (JA)

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Jürgen C Becker (JC)

Translational Skin Cancer Research, University Clinic Essen, Essen, Germany; Department of Dermatology, University Clinic Essen, Essen, Germany; German Cancer Consortium, German Cancer Center, Heidelberg, Germany.

Michael T Tetzlaff (MT)

Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: mtetzlaff@mdanderson.org.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Carcinome neuroendocrine › Carcinome à cellules de Merkel › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Métastase lymphatique › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Diagnostic › Pronostic › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › T-Cell Repertoire in Combination with T-Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › T-Cell Repertoire in Combination with T-Cell...