Iridoids and bis-iridoids from Valeriana jatamansi and their cytotoxicity against human glioma stem cells.

Humans Iridoids Molecular Structure Nardostachys Neoplastic Stem Cells Plant Roots Valerian
Bis-iridoids Caprifoliaceae Cytotoxicity Human glioma stem cells Iridoids Valeriana jatamansi Valeridoids A-F

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 13 12 2019
revised: 02 04 2020
accepted: 03 04 2020
pubmed: 20 4 2020
medline: 10 6 2020
entrez: 20 4 2020
Statut: ppublish

Résumé

An undescribed iridoid (valeridoid A) and five undescribed bis-iridoids (valeridoids B-F), along with four known ones, were isolated from the roots and rhizomes of Valeriana jatamansi. Their structures were elucidated based on 1D and 2D NMR, as well as HRESIMS spectroscopic data. In addition, 8,9-didehydro-7-hydroxydolichodial and valeridoid F were found to inhibit the growth of three human glioma stem cells (GSC-3#, GSC-12# and GSC-18#).

Identifiants

DOI: 10.1016/j.phytochem.2020.112372 PMID: 32305683
pubmed: 32305683
pii: S0031-9422(19)31201-4
doi: 10.1016/j.phytochem.2020.112372
pii:
doi:

Substances chimiques

Iridoids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112372

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Li-Qiu Quan (LQ)

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China.

Ahmed-Mohamed Hegazy (AM)

The First Department of Neurosurgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, 650101, Yunnan, PR China; Zoology Department, Faculty of Science, Minia University, Minia, 61519, Egypt.

Zhi-Jun Zhang (ZJ)

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China.

Xu-Dong Zhao (XD)

Laboratory of Animal Tumor Models, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, PR China; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, PR China. Electronic address: zhaoxudong@mail.kiz.ac.cn.

Hong-Mei Li (HM)

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: lihongmei0823@163.com.

Rong-Tao Li (RT)

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: rongtaolikm@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Iridoids and bis-iridoids from Valeriana...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrannes › Iridoïdes › Iridoids and bis-iridoids from Valeriana...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Iridoids and bis-iridoids from Valeriana...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Dipsacales › Valerianaceae › Nardostachys › Iridoids and bis-iridoids from Valeriana...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › Iridoids and bis-iridoids from Valeriana...
questionsmedicales.fr › Structures de plante › Racines de plante › Iridoids and bis-iridoids from Valeriana...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Dipsacales › Valerianaceae › Valeriana › Iridoids and bis-iridoids from Valeriana...