Heterogeneity in Brain Microstructural Development Following Preterm Birth.
biological heterogeneity
early brain development
neonatal MRI
neurodevelopment
prematurity
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
30 07 2020
30 07 2020
Historique:
received:
28
11
2019
revised:
24
01
2020
accepted:
23
02
2020
pubmed:
20
4
2020
medline:
15
12
2021
entrez:
20
4
2020
Statut:
ppublish
Résumé
Preterm-born children are at increased risk of lifelong neurodevelopmental difficulties. Group-wise analyses of magnetic resonance imaging show many differences between preterm- and term-born infants but do not reliably predict neurocognitive prognosis for individual infants. This might be due to the unrecognized heterogeneity of cerebral injury within the preterm group. This study aimed to determine whether atypical brain microstructural development following preterm birth is significantly variable between infants. Using Gaussian process regression, a technique that allows a single-individual inference, we characterized typical variation of brain microstructure using maps of fractional anisotropy and mean diffusivity in a sample of 270 term-born neonates. Then, we compared 82 preterm infants to these normative values to identify brain regions with atypical microstructure and relate observed deviations to degree of prematurity and neurocognition at 18 months. Preterm infants showed strikingly heterogeneous deviations from typical development, with little spatial overlap between infants. Greater and more extensive deviations, captured by a whole brain atypicality index, were associated with more extreme prematurity and predicted poorer cognitive and language abilities at 18 months. Brain microstructural development after preterm birth is highly variable between individual infants. This poorly understood heterogeneity likely relates to both the etiology and prognosis of brain injury.
Identifiants
pubmed: 32306044
pii: 5821448
doi: 10.1093/cercor/bhaa069
pmc: PMC7391275
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4800-4810Subventions
Organisme : Medical Research Council
ID : MC_U120088465
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206675/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203148/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K006355/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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