Heterogeneity in Brain Microstructural Development Following Preterm Birth.


Journal

Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718

Informations de publication

Date de publication:
30 07 2020
Historique:
received: 28 11 2019
revised: 24 01 2020
accepted: 23 02 2020
pubmed: 20 4 2020
medline: 15 12 2021
entrez: 20 4 2020
Statut: ppublish

Résumé

Preterm-born children are at increased risk of lifelong neurodevelopmental difficulties. Group-wise analyses of magnetic resonance imaging show many differences between preterm- and term-born infants but do not reliably predict neurocognitive prognosis for individual infants. This might be due to the unrecognized heterogeneity of cerebral injury within the preterm group. This study aimed to determine whether atypical brain microstructural development following preterm birth is significantly variable between infants. Using Gaussian process regression, a technique that allows a single-individual inference, we characterized typical variation of brain microstructure using maps of fractional anisotropy and mean diffusivity in a sample of 270 term-born neonates. Then, we compared 82 preterm infants to these normative values to identify brain regions with atypical microstructure and relate observed deviations to degree of prematurity and neurocognition at 18 months. Preterm infants showed strikingly heterogeneous deviations from typical development, with little spatial overlap between infants. Greater and more extensive deviations, captured by a whole brain atypicality index, were associated with more extreme prematurity and predicted poorer cognitive and language abilities at 18 months. Brain microstructural development after preterm birth is highly variable between individual infants. This poorly understood heterogeneity likely relates to both the etiology and prognosis of brain injury.

Identifiants

pubmed: 32306044
pii: 5821448
doi: 10.1093/cercor/bhaa069
pmc: PMC7391275
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4800-4810

Subventions

Organisme : Medical Research Council
ID : MC_U120088465
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206675/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203148/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K006355/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press.

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Auteurs

Ralica Dimitrova (R)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

Maximilian Pietsch (M)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Daan Christiaens (D)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, 3001, Belgium.

Judit Ciarrusta (J)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

Thomas Wolfers (T)

Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radbound University, Nijmegen, 6525EN, the Netherlands.
Department of Cognitive Neuroscience, Radbound University Medical Centre, Nijmegen, 6525EN, the Netherlands.

Dafnis Batalle (D)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

Emer Hughes (E)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Jana Hutter (J)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Lucilio Cordero-Grande (L)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Biomedical Image Technologies, ETSI Telecomunicacion, Universidad Politecnica de Madrid and CIBER-BBN, Madrid, 28040, Spain.

Anthony N Price (AN)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Andrew Chew (A)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Shona Falconer (S)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Katy Vecchiato (K)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.

Johannes K Steinweg (JK)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Olivia Carney (O)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Mary A Rutherford (MA)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

J-Donald Tournier (JD)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Serena J Counsell (SJ)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Andre F Marquand (AF)

Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radbound University, Nijmegen, 6525EN, the Netherlands.
Department of Cognitive Neuroscience, Radbound University Medical Centre, Nijmegen, 6525EN, the Netherlands.

Daniel Rueckert (D)

Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, SW7 2AZ, UK.

Joseph V Hajnal (JV)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.

Grainne McAlonan (G)

Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
South London and Maudsley NHS Foundation Trust, London, SE5 8AZ, UK.

A David Edwards (AD)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.

Jonathan O'Muircheartaigh (J)

Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.

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