Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid.
Acute exercise
Kynurenic acid
Kynurenines
Resistance exercise
Strenuous exercise
Tryptophan metabolism
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
03
12
2019
accepted:
09
04
2020
pubmed:
20
4
2020
medline:
18
3
2021
entrez:
20
4
2020
Statut:
ppublish
Résumé
Due to distinct immuno- and neuro-modulatory properties, growing research interest focuses on exercise-induced alterations of the kynurenine (KYN) pathway in healthy and clinical populations. To date, knowledge about the impact of different acute strength exercise modalities on the KYN pathway is scarce. Therefore, we investigated the acute effects of hypertrophic (HYP) compared to maximal (MAX) strength loadings on the KYN pathway regulation. Blood samples of twelve healthy males (mean age and weight: 23.5 ± 3.2 years; 77.5 ± 7.5 kg) were collected before (T The KA/KYN ratio increased from T Acute HYP loading led to increases in the metabolic flux yielding KA, thereby possibly promoting immunosuppression and neuroprotection. Our findings emphasize the potential of acute HYP exercise as short-term modulator of KYN pathway downstream to KA in healthy males and need to be proven in other samples.
Identifiants
pubmed: 32306154
doi: 10.1007/s00421-020-04375-9
pii: 10.1007/s00421-020-04375-9
pmc: PMC7237519
doi:
Substances chimiques
Kynurenine
343-65-7
Kynurenic Acid
H030S2S85J
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1429-1436Références
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