Germinotropic lymphoproliferative disorder: a systematic review.
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Coinfection
/ virology
Combined Modality Therapy
Diagnosis, Differential
Disease Progression
Female
Germinal Center
/ pathology
Herpesviridae Infections
/ diagnosis
Herpesvirus 4, Human
/ isolation & purification
Herpesvirus 8, Human
/ isolation & purification
Humans
Immunocompetence
Lymph Nodes
/ pathology
Lymphoma, Large B-Cell, Diffuse
/ virology
Lymphoma, Non-Hodgkin
/ virology
Lymphoma, Primary Effusion
/ diagnosis
Lymphoproliferative Disorders
/ diagnosis
Male
Middle Aged
Treatment Outcome
Disorder
Epstein-Barr virus
Germinotropic
Human herpesvirus 8
Lymphoproliferative
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
18
11
2019
accepted:
04
04
2020
pubmed:
21
4
2020
medline:
2
10
2020
entrez:
21
4
2020
Statut:
ppublish
Résumé
Germinotropic lymphoproliferative disorder is a rare and rather enigmatic novel entity with distinctive clinicopathological features, one of which is the typical co-infection by Human herpesvirus 8 and Epstein-Barr virus. Human herpesvirus 8 is a lymphotropic virus detected in Kaposi sarcoma, multicentric Castleman disease, primary effusion lymphoma, Human herpesvirus 8-positive diffuse large B cell lymphoma not otherwise specified, and germinotropic lymphoproliferative disorder. Co-infection by Human herpesvirus 8 and Epstein-Barr virus is identified only in two lymphoproliferative diseases: germinotropic lymphoproliferative disorder and primary effusion lymphoma, which are otherwise diseases with totally different clinical presentations and outcomes. Unlike primary effusion lymphoma mostly occurring in immunocompromised individuals and following an aggressive course, germinotropic lymphoproliferative disorder usually presents with single or multiple lymphadenopathy affecting mainly immunocompetent individuals and mostly follows an indolent course. Based on the PRISMA guidelines, we carried out a systematic search on PubMed/MEDLINE, Web of Science, Scopus, EMBASE, and Cochrane Library using the search terms "germinotropic" and "lymphoproliferative disorder." Current scientific literature reports just 19 cases of germinotropic lymphoproliferative disorder. The purpose of our systematic review is to improve our understanding of the disease, focusing on epidemiology, clinical presentation, pathological features, treatment, and outcome. In addition, we discuss the differential diagnosis with the other Human herpesvirus 8-related lymphoproliferative diseases as currently recognized in the World Health Organization classification, adding a focus on lymphoproliferative disorders showing overlapping features.
Identifiants
pubmed: 32307569
doi: 10.1007/s00277-020-04024-3
pii: 10.1007/s00277-020-04024-3
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2243-2253Références
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