Differences in correlations of depression and anhedonia with cardiovascular sympathetic functions during a head-up tilt test in drug-naïve Parkinson's disease patients.
Anhedonia
Cardiovascular sympathetic function
Depression
Orthostatic hypotension
Parkinson’s disease
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
23
10
2019
accepted:
01
04
2020
pubmed:
21
4
2020
medline:
15
5
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
Depression is a symptom of Parkinson's disease (PD) and may be correlated with cardiovascular sympathetic function. Anhedonia is an element of depression, but these symptoms can emerge independently in PD. A correlation of anhedonia with cardiovascular sympathetic function has rarely been examined. To compare correlations of depression and anhedonia with cardiovascular sympathetic function in drug-naive PD patients. Assessments of depression (Self-rating Depression Scale; SDS), anhedonia (Snaith-Hamilton Pleasure Scale; SHAPS), myocardial SDS significantly correlated with % maximum decrease in SBP (r = 0.344, p = 0.02), but not with H/M ratios in both images and increases in plasma NA and AVP levels. SHAPS did not correlate with the change in SBP, H/M ratios in both images, or plasma NA and AVP levels. Depression was correlated with the % maximum decrease in SBP during a 10-min HUT, but anhedonia did not show this relationship. This suggests that depression and anhedonia may have different pathophysiological backgrounds in drug-naïve PD patients.
Sections du résumé
BACKGROUND
BACKGROUND
Depression is a symptom of Parkinson's disease (PD) and may be correlated with cardiovascular sympathetic function. Anhedonia is an element of depression, but these symptoms can emerge independently in PD. A correlation of anhedonia with cardiovascular sympathetic function has rarely been examined.
OBJECTIVE
OBJECTIVE
To compare correlations of depression and anhedonia with cardiovascular sympathetic function in drug-naive PD patients.
METHODS
METHODS
Assessments of depression (Self-rating Depression Scale; SDS), anhedonia (Snaith-Hamilton Pleasure Scale; SHAPS), myocardial
RESULTS
RESULTS
SDS significantly correlated with % maximum decrease in SBP (r = 0.344, p = 0.02), but not with H/M ratios in both images and increases in plasma NA and AVP levels. SHAPS did not correlate with the change in SBP, H/M ratios in both images, or plasma NA and AVP levels.
CONCLUSION
CONCLUSIONS
Depression was correlated with the % maximum decrease in SBP during a 10-min HUT, but anhedonia did not show this relationship. This suggests that depression and anhedonia may have different pathophysiological backgrounds in drug-naïve PD patients.
Identifiants
pubmed: 32307665
doi: 10.1007/s10072-020-04390-w
pii: 10.1007/s10072-020-04390-w
doi:
Substances chimiques
Pharmaceutical Preparations
0
3-Iodobenzylguanidine
35MRW7B4AD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM