Molecular networks in Network Medicine: Development and applications.
big data
molecular networks
network medicine
Journal
Wiley interdisciplinary reviews. Systems biology and medicine
ISSN: 1939-005X
Titre abrégé: Wiley Interdiscip Rev Syst Biol Med
Pays: United States
ID NLM: 101516550
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
23
11
2019
revised:
29
02
2020
accepted:
20
03
2020
pubmed:
21
4
2020
medline:
21
10
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
Network Medicine applies network science approaches to investigate disease pathogenesis. Many different analytical methods have been used to infer relevant molecular networks, including protein-protein interaction networks, correlation-based networks, gene regulatory networks, and Bayesian networks. Network Medicine applies these integrated approaches to Omics Big Data (including genetics, epigenetics, transcriptomics, metabolomics, and proteomics) using computational biology tools and, thereby, has the potential to provide improvements in the diagnosis, prognosis, and treatment of complex diseases. We discuss briefly the types of molecular data that are used in molecular network analyses, survey the analytical methods for inferring molecular networks, and review efforts to validate and visualize molecular networks. Successful applications of molecular network analysis have been reported in pulmonary arterial hypertension, coronary heart disease, diabetes mellitus, chronic lung diseases, and drug development. Important knowledge gaps in Network Medicine include incompleteness of the molecular interactome, challenges in identifying key genes within genetic association regions, and limited applications to human diseases. This article is categorized under: Models of Systems Properties and Processes > Mechanistic Models Translational, Genomic, and Systems Medicine > Translational Medicine Analytical and Computational Methods > Analytical Methods Analytical and Computational Methods > Computational Methods.
Identifiants
pubmed: 32307915
doi: 10.1002/wsbm.1489
pmc: PMC7955589
mid: NIHMS1675315
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1489Subventions
Organisme : NIH HHS
ID : P01HL105339
Pays : United States
Organisme : NIH HHS
ID : P01HL114501
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133135
Pays : United States
Organisme : NIH HHS
ID : P50GM107618
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM107618
Pays : United States
Organisme : NIH HHS
ID : K25HL133599
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137927
Pays : United States
Organisme : NIH HHS
ID : U01HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL114501
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111759
Pays : United States
Organisme : NIH HHS
ID : U01HG007690
Pays : United States
Organisme : NIH HHS
ID : R01HL147148
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007690
Pays : United States
Organisme : NHLBI NIH HHS
ID : K25 HL133599
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147148
Pays : United States
Organisme : NHLBI NIH HHS
ID : U54 HL119145
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220523
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL105339
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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