Epoxyeicosatrienoic acid metabolites inhibit Kir4.1/Kir5.1 in the distal convoluted tubule.
8,11,14-Eicosatrienoic Acid
/ analogs & derivatives
Amides
/ pharmacology
Animals
Arachidonic Acid
/ metabolism
Cytochrome P450 Family 2
/ antagonists & inhibitors
Enzyme Inhibitors
/ pharmacology
Kidney Tubules, Distal
/ drug effects
Male
Membrane Potentials
Mice, 129 Strain
Mice, Knockout
Potassium Channel Blockers
/ metabolism
Potassium Channels, Inwardly Rectifying
/ antagonists & inhibitors
Na+-Cl− cotransporter
aldosterone-sensitive distal nephron
cytochrome P-450 epoxygenase
eicosanoids
hypertension
thiazide sensitive
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
pubmed:
21
4
2020
medline:
8
10
2020
entrez:
21
4
2020
Statut:
ppublish
Résumé
Cytochrome
Identifiants
pubmed: 32308018
doi: 10.1152/ajprenal.00018.2020
pmc: PMC7311705
doi:
Substances chimiques
Amides
0
Enzyme Inhibitors
0
Kcnj10 (channel)
0
Kcnj16 protein, mouse
0
N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide
0
Potassium Channel Blockers
0
Potassium Channels, Inwardly Rectifying
0
Arachidonic Acid
27YG812J1I
11,12-epoxy-5,8,14-eicosatrienoic acid
5DOQ38R4UW
14,15-epoxy-5,8,11-eicosatrienoic acid
81276-03-1
Cyp2c23 protein, mouse
EC 1.14.14.1
Cytochrome P450 Family 2
EC 1.14.14.1
8,11,14-Eicosatrienoic Acid
FC398RK06S
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
F1369-F1376Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK054983
Pays : United States
Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : DK54983
Pays : International
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