An overview on natural farnesyltransferase inhibitors for efficient cancer therapy.
FTIs
Ras protein
Tumour
inhibitors
natural materials
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
entrez:
21
4
2020
pubmed:
21
4
2020
medline:
22
12
2020
Statut:
ppublish
Résumé
As one of the world's five terminally ills, tumours can cause important genetic dysfunction. However, some current medicines for tumours usually have strong toxic side effects and are prone to drug resistance. Studies have found that farnesyltransferase inhibitors (FTIs) extracted from natural materials have a good inhibiting ability on tumours with fewer side effects. This article describes several FTIs extracted from natural materials and clarifies the current research progress, which provides a new choice for the treatment of tumours.
Identifiants
pubmed: 32308053
doi: 10.1080/14756366.2020.1732366
pmc: PMC7191900
doi:
Substances chimiques
Antineoplastic Agents
0
Biological Products
0
Enzyme Inhibitors
0
Farnesyltranstransferase
EC 2.5.1.29
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1027-1044Références
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