Evaluation of Efficacy of Curcumin along with Lycopene and Piperine in the Management of Oral Submucous Fibrosis.
Curcumin
lycopene
mouth opening
mucosal flexibility
oral submucous fibrosis
piperine
visual Analog Scale score for burning sensation
Journal
Contemporary clinical dentistry
ISSN: 0976-237X
Titre abrégé: Contemp Clin Dent
Pays: India
ID NLM: 101552967
Informations de publication
Date de publication:
Historique:
entrez:
21
4
2020
pubmed:
21
4
2020
medline:
21
4
2020
Statut:
ppublish
Résumé
Oral submucous fibrosis (OSMF) is a high-risk premalignant condition of the oral cavity and oropharynx. Complete regression of the disease is still not possible with available treatment modalities. The aim of the study was to evaluate the efficacy of curcumin, lycopene, and piperine as a combination in the management of OSMF. Efficacy was evaluated on the basis of improvement in clinical parameters (i.e., visual Analog Scale [VAS]) score for burning sensation, mouth opening (MO), mucosal flexibility (MF), and tongue protrusion [TP]). Forty patients clinically and histopathologically diagnosed with OSMF were included in the study; patients were administered with the above-stated drug combination, and clinical parameters were evaluated at regular intervals to compare the pre- and post-treatment measurements. Paired Highly significant improvement was observed for posttreatment reduction in VAS score for burning sensation and increase in MO ( Taken together, the present study proposes the usage of combination drug therapy for the management of OSMF as an effective and affordable way.
Identifiants
pubmed: 32308333
doi: 10.4103/ccd.ccd_937_18
pii: CCD-10-531
pmc: PMC7150573
doi:
Types de publication
Journal Article
Langues
eng
Pagination
531-541Informations de copyright
Copyright: © 2020 Contemporary Clinical Dentistry.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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