Blue Woman Syndrome and Thyrotoxicosis in a Patient on Amiodarone.
Amiodarone
adverse drug reaction
atrial fibrillation
hyperthyroidism
skin pigmentation
Journal
European journal of case reports in internal medicine
ISSN: 2284-2594
Titre abrégé: Eur J Case Rep Intern Med
Pays: Italy
ID NLM: 101648453
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
01
2020
accepted:
27
01
2020
entrez:
21
4
2020
pubmed:
21
4
2020
medline:
21
4
2020
Statut:
epublish
Résumé
Amiodarone is an antiarrhythmic drug, in use from the 1960s, which acts on potassium transport in myocytes, causing a lengthening of the action potential and refractory period. Even though it is broadly prescribed, its use is limited by a relatively high occurrence of adverse reactions such as lung, thyroid or hepatic disease, skin changes and so on. The authors report a case of a female patient who was admitted due to chest pain. Due to the bluish skin pigmentation, other causes of amiodarone toxicity were investigated, and hyperthyroidism was detected. After amiodarone discontinuation and specific therapy, thyroid function returned to normal. Blue pigmentation of facial skin is an uncommon adverse effect of chronic amiodarone therapy that occurs in less than 3% of patients.When a patient is on chronic amiodarone therapy, signs of toxicity, such as hyperthyroidism, lung injury or hepatic disease, should be investigated.Regular liver and thyroid function tests and chest x-rays should be carried out on follow-up after initiation of amiodarone.
Identifiants
pubmed: 32309263
doi: 10.12890/2020_001526
pii: 1526-1-12072-2-10-20200228
pmc: PMC7162571
doi:
Types de publication
Journal Article
Langues
eng
Pagination
001526Informations de copyright
© EFIM 2020.
Déclaration de conflit d'intérêts
Conflicts of Interests: The Authors declare that there are no competing interests.
Références
Am J Med. 2016 May;129(5):468-75
pubmed: 26497904
CMAJ. 2018 Feb 5;190(5):E139
pubmed: 29431112
J Geriatr Cardiol. 2019 Jul;16(7):552-566
pubmed: 31447894
Eur Thyroid J. 2018 Mar;7(2):55-66
pubmed: 29594056
CMAJ. 2016 May 17;188(8):604
pubmed: 26858350
Ann Endocrinol (Paris). 2019 Feb;80(1):54-60
pubmed: 30236455