Functional Profiling of FSH and Estradiol in Ovarian Granulosa Cell Tumors.

aromatase estrogen receptor granulosa cell tumor hormonal treatment

Journal

Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997

Informations de publication

Date de publication:
01 Apr 2020
Historique:
received: 10 10 2019
accepted: 11 03 2020
entrez: 21 4 2020
pubmed: 21 4 2020
medline: 21 4 2020
Statut: epublish

Résumé

Adult-type granulosa cell tumors (AGCTs) are sex-cord derived neoplasms with a propensity for late relapse. Hormonal modulators have been used empirically in the treatment of recurrent AGCT, albeit with limited success. To provide a more rigorous foundation for hormonal therapy in AGCT, we used a multimodal approach to characterize the expressions of key hormone biomarkers in 175 tumor specimens and 51 serum samples using RNA sequencing, immunohistochemistry, RNA

Identifiants

pubmed: 32309755
doi: 10.1210/jendso/bvaa034
pii: bvaa034
pmc: PMC7153750
doi:

Types de publication

Journal Article

Langues

eng

Pagination

bvaa034

Informations de copyright

© Endocrine Society 2020.

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Auteurs

Ulla-Maija Haltia (UM)

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Children's Hospital and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Marjut Pihlajoki (M)

Children's Hospital and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Noora Andersson (N)

Children's Hospital and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Lotta Mäkinen (L)

Children's Hospital and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Johanna Tapper (J)

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Alejandra Cervera (A)

Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Hugo M Horlings (HM)

Department of Pathology, the Netherlands Cancer Institute, BE Amsterdam, the Netherlands.

Ursula Turpeinen (U)

HUSLAB, Helsinki University Hospital, Helsinki, Finland.

Mikko Anttonen (M)

HUSLAB, Helsinki University Hospital, Helsinki, Finland.

Ralf Bützow (R)

Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Leila Unkila-Kallio (L)

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Olli Carpén (O)

Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

David B Wilson (DB)

Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri 63110.
Department of Developmental Biology, Washington University School of Medicine, Saint Louis, Missouri 63110.

Markku Heikinheimo (M)

Children's Hospital and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri 63110.

Anniina Färkkilä (A)

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Classifications MeSH