Blastomycosis in Minnesota, USA, 1999-2018.
Blastomyces
Minnesota
United States
antifungal agents
blastomycosis
delayed diagnosis
endemic diseases
epidemiology
fungi
geography
incidence
inhalation exposure
itraconazole
lung diseases
pneumonia
public health
risk factors
sex ratio
travel
treatment outcome
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
entrez:
21
4
2020
pubmed:
21
4
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Blastomycosis is a systemic disease caused by Blastomyces spp. fungi. To determine its epidemiology in blastomycosis-endemic Minnesota, USA, we evaluated all cases reported to public health officials during 1999-2018. We focused on time to diagnosis, exposure activities, and exposure location. A total of 671 cases and a median of 34 cases/year were reported. Median time to diagnosis was 31 days; 61% of patients were not tested for blastomycosis until they were hospitalized. The case-fatality rate was 10%, and patients who died were 5.3 times more likely to have a concurrent medical condition. Outdoor activities and soil exposure were reported by many patients, but no specific activity or exposure was common to most. Almost one third of patients were probably exposed in geographic areas other than their home county. Providers should consider alternative etiologies for patients with pneumonia not responding to antibacterial treatment, and public health officials should increase awareness in blastomycosis-endemic areas.
Identifiants
pubmed: 32310071
doi: 10.3201/eid2605.191074
pmc: PMC7181909
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
866-875Subventions
Organisme : NCEZID CDC HHS
ID : U50 CK000371
Pays : United States
Références
Emerg Infect Dis. 2018 Jul;24(7):1257-1266
pubmed: 29912691
Open Forum Infect Dis. 2016 Apr 19;3(2):ofw078
pubmed: 27419155
Med Mycol. 2018 Oct 1;56(7):787-795
pubmed: 29924358
Clin Infect Dis. 2005 Dec 15;41(12):e107-11
pubmed: 16288388
Chest. 1984 Nov;86(5):688-92
pubmed: 6488903
Epidemiol Infect. 2003 Oct;131(2):907-14
pubmed: 14596532
Clin Infect Dis. 2019 Jan 7;68(2):188-195
pubmed: 29878145
Clin Microbiol Rev. 2011 Apr;24(2):296-313
pubmed: 21482727
Am Rev Respir Dis. 1987 Dec;136(6):1333-8
pubmed: 3688635
Chest. 2015 Nov;148(5):1276-1284
pubmed: 26020566
J Fungi (Basel). 2018 Apr 18;4(2):
pubmed: 29670032
J Infect Dis. 1987 Mar;155(3):568-70
pubmed: 3805778
J Infect Dis. 2013 Mar 1;207(5):814-22
pubmed: 23230057
mBio. 2019 Jun 18;10(3):
pubmed: 31213563
N Engl J Med. 1986 Feb 27;314(9):529-34
pubmed: 3945290
Respir Med. 2012 Jun;106(6):769-76
pubmed: 22386326
PLoS One. 2013;8(3):e59237
pubmed: 23533607
Can J Infect Dis Med Microbiol. 2015 Sep-Oct;26(5):259-62
pubmed: 26600814
Clin Infect Dis. 2013 Sep;57(5):655-62
pubmed: 23735332
PLoS One. 2008 Apr 30;3(4):e2034
pubmed: 18446224
Infect Dis Clin North Am. 2016 Mar;30(1):247-64
pubmed: 26739607
Ann Diagn Pathol. 2002 Jun;6(3):194-203
pubmed: 12089732
PLoS One. 2016 Jul 18;11(7):e0159396
pubmed: 27428521
J Infect Dis. 2014 Jul 15;209 Suppl 3:S107-13
pubmed: 24966190
Clin Microbiol Rev. 2010 Apr;23(2):367-81
pubmed: 20375357
Infect Dis Clin North Am. 2003 Mar;17(1):21-40, vii
pubmed: 12751259
Clin Med Res. 2011 Jun;9(2):57-65
pubmed: 20974888
Emerg Infect Dis. 2014 Nov;20(11):1789-94
pubmed: 25339251
J Pediatric Infect Dis Soc. 2017 Mar 1;6(1):49-56
pubmed: 26703241
Epidemiol Infect. 2013 Jun;141(6):1143-7
pubmed: 22929032