Optoacoustic mesoscopy shows potential to increase accuracy of allergy patch testing.
allergy
contact dermatitis
optoacoustic imaging
patch test
photoacoustic imaging
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
15
01
2020
revised:
11
04
2020
accepted:
16
04
2020
pubmed:
21
4
2020
medline:
29
5
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
Differentiation between irritant and allergic skin reactions in epicutaneous patch testing is based largely on subjective clinical criteria, with the risk of high intraobserver and interobserver variability. Novel dermatological imaging using optoacoustic mesoscopy allows quantitative three-dimensional assessment of microvascular biomarkers. We investigated the potential of optoacoustic imaging to improve the precision of patch test evaluation. Sixty-nine test reactions and 48 healthy skin sections in 52 patients with suspected type IV allergy were examined using raster-scan optoacoustic mesoscopy. We identified biomarkers from the optoacoustic images. Allergic reactions were associated with higher fragmentation of skin vasculature than irritant reactions (19.5 ± 9.7 vs 14.3 ± 3.7 fragments/100 pixels Optoacoustic mesoscopy shows potential to help in differentiating between allergic and irritant test reactions based on novel biomarkers that may reflect vasodilation, vessel tortuosity, and edema.
Sections du résumé
BACKGROUND
BACKGROUND
Differentiation between irritant and allergic skin reactions in epicutaneous patch testing is based largely on subjective clinical criteria, with the risk of high intraobserver and interobserver variability. Novel dermatological imaging using optoacoustic mesoscopy allows quantitative three-dimensional assessment of microvascular biomarkers.
OBJECTIVES
OBJECTIVE
We investigated the potential of optoacoustic imaging to improve the precision of patch test evaluation.
METHODS
METHODS
Sixty-nine test reactions and 48 healthy skin sections in 52 patients with suspected type IV allergy were examined using raster-scan optoacoustic mesoscopy.
RESULTS
RESULTS
We identified biomarkers from the optoacoustic images. Allergic reactions were associated with higher fragmentation of skin vasculature than irritant reactions (19.5 ± 9.7 vs 14.3 ± 3.7 fragments/100 pixels
CONCLUSIONS
CONCLUSIONS
Optoacoustic mesoscopy shows potential to help in differentiating between allergic and irritant test reactions based on novel biomarkers that may reflect vasodilation, vessel tortuosity, and edema.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-214Informations de copyright
© 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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