Structural basis for the modulation of pentameric ligand-gated ion channel function by lipids.
Allosteric modulation
Annular
Lipid binding sites
Lipid-protein interactions
Non-annular
Pentameric ligand-gated ion channels
Journal
Biochimica et biophysica acta. Biomembranes
ISSN: 1879-2642
Titre abrégé: Biochim Biophys Acta Biomembr
Pays: Netherlands
ID NLM: 101731713
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
31
12
2019
revised:
20
03
2020
accepted:
05
04
2020
pubmed:
21
4
2020
medline:
15
12
2020
entrez:
21
4
2020
Statut:
ppublish
Résumé
Pentameric ligand-gated ion channels (pLGICs) play a central role in synaptic communication and are implicated in a plethora of neurological disorders leading to human disease. Membrane lipids are known to modulate pLGIC function, but the mechanisms underlying their effects are poorly understood. Recent structures reveal sites for the binding of membrane lipids to pLGICs, thus providing a structural basis for interpreting functional data on pLGIC-lipid interactions. Here, we review the literature describing the known functional effects of membrane lipids on different members of the pLGIC superfamily and highlight pLGIC structures that exhibit bound lipids. We discuss new insight into the mechanisms of pLGIC-lipid interactions that has been derived from these recent structures.
Identifiants
pubmed: 32311340
pii: S0005-2736(20)30135-8
doi: 10.1016/j.bbamem.2020.183304
pii:
doi:
Substances chimiques
Ligand-Gated Ion Channels
0
Lipids
0
Membrane Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
183304Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.