Serum levels of C1q/TNF-related protein-3 in inflammatory bowel disease patients and its inverse association with inflammatory cytokines and insulin resistance.
Adipokines
/ blood
Adiponectin
/ blood
Adult
Colitis, Ulcerative
/ blood
Crohn Disease
/ blood
Cytokines
/ blood
Female
Humans
Inflammatory Bowel Diseases
/ blood
Insulin
/ blood
Insulin Resistance
/ genetics
Interleukin-6
/ blood
Male
Transforming Growth Factor beta
/ blood
Tumor Necrosis Factor-alpha
/ blood
Tumor Necrosis Factors
/ blood
CTRP3
Crohn's disease
IBD
ulcerative colitis
Journal
IUBMB life
ISSN: 1521-6551
Titre abrégé: IUBMB Life
Pays: England
ID NLM: 100888706
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
04
03
2020
revised:
05
04
2020
accepted:
07
04
2020
pubmed:
21
4
2020
medline:
24
11
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
Ulcerative colitis (UC) and Crohn's disease (CD) are two major forms of inflammatory bowel disease (IBD), which is an inflammatory disease. Studies have shown that adipose tissue and inflammation play important roles in the pathogenesis of IBD. C1q/TNF-related protein-3 (CTRP3) is a newly discovered adipokine playing a substantial role during inflammatory process, and for the first time in the present study, serum levels of this adipokine were measured in the UC and CD patients. This case-control study included 70 control, 50 UC, and 50 CD patients who were diagnosed by standard criteria. Serum levels of adiponectin, IL-6, TNF-α, TGF-β, and CTRP3 were evaluated using ELISA kits. Serum levels of IL-6, TNF-α, and TGF-β elevated in the UC and CD patients compared with the controls while adiponectin and CTRP3 diminished in the patient's groups compared with the control. Furthermore, decrease in CTRP3 serum levels was associated with the risk of UC and CD diseases. Moreover, CTRP3 indicated negative correlation with BMI, FBS, insulin, homeostasis model assessment of insulin resistance, IL-6, TNF-α, and TGF-β and also a positive correlation with adiponectin in both the UC and CD patients. For the first time, the present study demonstrated lower levels of CTRP3 in the UC and CD patients. Decreased serum levels of CTRP3 and its inverse relationship with inflammatory cytokines and TGF-β levels suggested a possible role for CTRP3 in the pathogenesis of UC and CD diseases.
Substances chimiques
Adipokines
0
Adiponectin
0
C1QTNF3 protein, human
0
Cytokines
0
Insulin
0
Interleukin-6
0
Transforming Growth Factor beta
0
Tumor Necrosis Factor-alpha
0
Tumor Necrosis Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1698-1704Informations de copyright
© 2020 International Union of Biochemistry and Molecular Biology.
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